{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T22:32:26Z","timestamp":1766269946397},"reference-count":15,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,3,11]],"date-time":"2012-03-11T00:00:00Z","timestamp":1331424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p>We present an unusual case of a CD56\u2010positive T\u2010cell lymphoma exhibiting immunophenotypic characteristics of both \u03b3\u03b4 T\u2010cell lymphoma and extranodal NK\/T\u2010cell lymphoma, nasal\u2010type. The patient presented with a 2\u2010month history of rapidly progressive, pruritic and cutaneous nodules on his arms. A biopsy showed a dense pan\u2010dermal infiltrate of markedly atypical CD3\u2010positive lymphocytes, compatible with tumor stage cutaneous T\u2010cell lymphoma. Retrospective review of a preceding biopsy and flow cytometric analysis, performed at an outside institution, showed strong expression of surface CD3, CD7, CD43 and \u03b3\u03b4 T\u2010cell receptor (TCR), findings consistent with a diagnosis of cutaneous \u03b3\u03b4 T\u2010cell lymphoma. In light of these data, we performed additional studies that showed diffuse positive staining of the atypical lymphocytes for CD56, CD4 and CD43 as well as Epstein\u2013Barr virus\u2010encoded small nonpolyadenylated RNA (EBER). Interestingly, this case displays characteristic features of \u03b3\u03b4 T\u2010cell lymphoma, with strong surface expression of CD3 and \u03b3\u03b4\u2010TCR, as well as characteristics of natural killer (NK)\/T\u2010cell lymphoma, including expression of CD4 and EBER positivity, that represent two separate categories in the current classification of cutaneous lymphomas. Taken together, these findings underscore the difficulty of rendering an unambiguous classification of the presented neoplasm given the close ontogenetic relationship between NK and cytotoxic T\u2010cells and highlight the need for continued reevaluation of the current classification system.<\/jats:p><jats:p>Schieke SM, Sharaf MA, Lerner A, R\u00fcnger TM, Mahalingam M. Primary cutaneous CD56 positive lymphoma: a diagnostic conundrum in an unusual case of lymphoma.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2012.01874.x","type":"journal-article","created":{"date-parts":[[2012,3,12]],"date-time":"2012-03-12T04:21:48Z","timestamp":1331526108000},"page":"540-544","source":"Crossref","is-referenced-by-count":11,"title":["Primary cutaneous CD56 positive lymphoma: a diagnostic conundrum in an unusual case of lymphoma"],"prefix":"10.1111","volume":"39","author":[{"given":"Stefan M.","family":"Schieke","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A.","family":"Sharaf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adam","family":"Lerner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas M.","family":"R\u00fcnger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meera","family":"Mahalingam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,3,11]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3502"},{"key":"e_1_2_4_3_2","volume-title":"WHO classification: pathology and genetics of tumors of haematopoietic and lymphoid tissues.","author":"Swerdlow SH","year":"2008"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31821ec4b5"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2006.042135"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-04-087288"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e31822067d1"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2009.169"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.136.8.1024"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01758.x"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.3.708"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2010.255"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2797"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20001115)89:10<2106::AID-CNCR11>3.0.CO;2-G"},{"key":"e_1_2_4_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1346-8138.2002.tb00196.x"},{"key":"e_1_2_4_16_2","doi-asserted-by":"crossref","first-page":"2688.","DOI":"10.1182\/blood.V81.10.2688.2688","article-title":"Nasal T\u2010cell lymphoma: a clinicopathologic entity associated with a peculiar phenotype and with Epstein\u2013Barr virus.","volume":"81","author":"Kanavaros P","year":"1993","journal-title":"Blood"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2012.01874.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2012.01874.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T07:21:36Z","timestamp":1697440896000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2012.01874.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,3,11]]},"references-count":15,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["10.1111\/j.1600-0560.2012.01874.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2012.01874.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,3,11]]}}}