{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T06:42:24Z","timestamp":1791096144313,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,4,20]],"date-time":"2012-04-20T00:00:00Z","timestamp":1334880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,5]]},"abstract":"<jats:p><jats:bold>Background:<\/jats:bold> The mechanisms of tumor progression in mycosis fungoides (MF) and S\u00e9zary syndrome (SS) are poorly understood. Twist, a transcription factor, is thought to promote solid tumor progression by blocking p53 and inhibiting c\u2010myc\u2010induced apoptosis. Whether Twist expression is correlated to MF\/SS stages remains unknown.<\/jats:p><jats:p><jats:bold>Methods:<\/jats:bold> Twist, c\u2010myc and p53 proteins in 68 MF\/SS lesions across all T stages were examined by immunohistochemistry, and mRNA levels in peripheral blood CD4+ T\u2010cells from SS patients were measured by real\u2010time quantitative polymerase chain reaction.<\/jats:p><jats:p><jats:bold>Results:<\/jats:bold> Positive staining for Twist was found in 12.5% (2\/16) of T1 and 33.3% (7\/21) of T2 early stage patches\/plaques compared to 50.0% (9\/18) of T3 tumors and 84.6% (11\/13) of T4 erythroderma. Most T4 erythroderma were positive for Twist in dermal lymphocytes, with the strongest staining. Positive staining for c\u2010myc was higher in T3\/T4 lesions (29\/31, 93.5%) than T1\/T2 lesions (25\/37, 67.6%, p &lt; 0.05), with strongest staining in T3 tumors. Aberrant p53 expression was more common in T3\/T4 lesions (8\/31, 25.8%) than in T1\/T2 lesions (2\/37, 5.4%, p &lt; 0.05). Twist mRNA was detected in all CD4+ T cells from SS patients but not in normal donors.<\/jats:p><jats:p><jats:bold>Conclusions:<\/jats:bold> Increased Twist protein expression in advanced MF\/SS lesions suggests that Twist expression may correlate with MF\/SS stages.<\/jats:p><jats:p>Goswami M, Duvic M, Dougherty A, Ni X. Increased Twist expression in advanced stage of mycosis fungoides and S\u00e9zary syndrome.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2012.01883.x","type":"journal-article","created":{"date-parts":[[2012,2,3]],"date-time":"2012-02-03T18:13:58Z","timestamp":1328292838000},"page":"500-507","source":"Crossref","is-referenced-by-count":33,"title":["Increased Twist expression in advanced stage of mycosis fungoides and S\u00e9zary 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