{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,13]],"date-time":"2025-10-13T09:04:38Z","timestamp":1760346278443},"reference-count":24,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T00:00:00Z","timestamp":1341446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The histopathologic distinction between benign and malignant cutaneous keratinocytic proliferations can pose a difficult diagnostic challenge \u2013 often with important clinical implications. Activating transcription factor 3 (<jats:styled-content style=\"fixed-case\">ATF3<\/jats:styled-content>) has emerged as a potential biomarker which may aid in the segregation of these lesions, and we hypothesize that <jats:styled-content style=\"fixed-case\">ATF3<\/jats:styled-content> expression may be a specific marker of cutaneous squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>). Using immunohistochemistry, we characterized <jats:styled-content style=\"fixed-case\">ATF3<\/jats:styled-content> expression in a series of 126 cutaneous epithelial proliferations, including <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> (n\u2009=\u200927), basal cell carcinomas (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>, n\u2009=\u200959), seborrheic keratoses with atypia (<jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content>, n\u2009=\u200916), hyperplastic actinic keratoses (<jats:styled-content style=\"fixed-case\">AK<\/jats:styled-content>, n\u2009=\u200912) and prurigo nodularis cases (<jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>, n\u2009=\u200912). We showed strong, nuclear and\/or nucleolar expression of <jats:styled-content style=\"fixed-case\">ATF3<\/jats:styled-content> in a statistically significant number of cases of <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> compared to <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">SK<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">PN<\/jats:styled-content>. We conclude that <jats:styled-content style=\"fixed-case\">ATF3<\/jats:styled-content> expression is a surrogate of malignancy (or pre\u2010malignancy) in keratinocytic epithelial proliferations and thus helps distinguish <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> from other cutaneous epithelial neoplasms.<\/jats:p>","DOI":"10.1111\/j.1600-0560.2012.01938.x","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T01:51:04Z","timestamp":1341539464000},"page":"762-768","source":"Crossref","is-referenced-by-count":5,"title":["The utility of <scp>ATF3<\/scp> in distinguishing cutaneous squamous cell carcinoma among other cutaneous epithelial neoplasms"],"prefix":"10.1111","volume":"39","author":[{"given":"Crystal L.","family":"Rose","sequence":"first","affiliation":[{"name":"Department of Pathology, Section of Dermatopathology The University of Texas MD Anderson Cancer Center  Houston TX 77030 USA"},{"name":"Department of 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