{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,26]],"date-time":"2025-11-26T21:53:16Z","timestamp":1764193996966},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T00:00:00Z","timestamp":1344470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Herpetic dermatitis due to herpes simplex virus (<jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>) and varicella zoster virus (<jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>) can present with similar clinical and histopathologic features. Further confounding matters, viral cytopathic changes are not always observed in biopsy specimens. Therefore, use of polymerase chain reaction (<jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content>) analysis can play an integral role in the definitive diagnosis of herpetic dermatitis and in the distinction of <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101\/<jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20102 from <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty patients with skin biopsies (2004\u20132011) had <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> analysis performed to detect <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content>\u20101\/2 or <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content>. Patient demographics, clinical impression and histopathologic characteristics were reviewed and correlated with <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, there was complete correlation between clinical impression, histopathology and <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> results in 21 of 40 cases. In 19 cases, clinical impression and histopathology were discrepant and in 15 of these cases <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> confirmed <jats:styled-content style=\"fixed-case\">HSV<\/jats:styled-content> or <jats:styled-content style=\"fixed-case\">VZV<\/jats:styled-content> infection. We also describe 3 cases of herpetic dermatitis without viral change that histopathologically demonstrate the pattern of a dermal hypersensitivity reaction.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The results of this study suggest that routine use of <jats:styled-content style=\"fixed-case\">PCR<\/jats:styled-content> for definitive diagnosis of herpetic dermatitis should be considered when there is a clinical suspicion of herpes virus infection, even when there is a lack of specific histopathologic findings. Additionally, a dermal hypersensitivity reaction should be recognized as one histopathologic manifestation of herpes incognito.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0560.2012.01963.x","type":"journal-article","created":{"date-parts":[[2012,8,9]],"date-time":"2012-08-09T07:15:23Z","timestamp":1344496523000},"page":"929-935","source":"Crossref","is-referenced-by-count":6,"title":["Dermal hypersensitivity reaction: a <scp>PCR<\/scp>\u2010confirmed pattern of herpetic dermatitis"],"prefix":"10.1111","volume":"39","author":[{"given":"Christopher L.","family":"Kinonen","sequence":"first","affiliation":[{"name":"Department of Pathology, NorthShore University Health System  Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Briana C.","family":"Gleason","sequence":"additional","affiliation":[{"name":"Diagnostic Pathology Medical Group  Sacramento CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antoinette B.","family":"Thomas","sequence":"additional","affiliation":[{"name":"Department of Pathology, NorthShore University Health System  Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen L.","family":"Kaul","sequence":"additional","affiliation":[{"name":"Department of Pathology, NorthShore University Health System  Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas L.","family":"Cibull","sequence":"additional","affiliation":[{"name":"Department of Pathology, NorthShore University Health System  Evanston IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,8,9]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.26717"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200004000-00010"},{"key":"e_1_2_5_4_1","first-page":"1608","article-title":"Herpes virus infection of the skin: new histopathologic clues to the diagnosis","volume":"120","author":"Austin C","year":"1984","journal-title":"Arch Dermatol"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-198906000-00011"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)80099-7"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(98)70076-3"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1997.18161913.x"},{"key":"e_1_2_5_9_1","first-page":"613","volume-title":"Weedon's skin pathology","author":"Weedon D","year":"2010"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000199858.56090.32"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00430-003-0202-1"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70103-9"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2008.02587.x"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1974.tb01769.x"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.dad.0000158300.48286.2d"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/jmv.21506"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.19.1.165-256.2006"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2003.08.006"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)91450-1"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2012.01963.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2012.01963.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:23:55Z","timestamp":1700565835000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2012.01963.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8,9]]},"references-count":18,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2012,10]]}},"alternative-id":["10.1111\/j.1600-0560.2012.01963.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2012.01963.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,8,9]]}}}