{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T22:43:01Z","timestamp":1780440181666,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T00:00:00Z","timestamp":1343174400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous granulomatous inflammation can occur in patients with T\u2010cell lymphoma and Hodgkin disease. We describe the unusual microscopic pattern of a granuloma annulare (GA)\u2010like eruption co\u2010existing with B\u2010cell chronic lymphocytic leukemia (B\u2010<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We reviewed the histopathology and immunophenotype of skin biopsies from two patients with B\u2010<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> and cutaneous lesions resembling GA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both patients had symptomatic cutaneous lesions clinically resembling GA; one had lesions refractory to standard dermatologic therapy. Histopathology showed GA\u2010like palisaded histiocytic infiltration, with subtle collections of lymphocytes interspersed among the granulomatous inflammation. Immunohistochemistry showed strong expression of <jats:styled-content style=\"fixed-case\">CD20<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD79a<\/jats:styled-content>, with aberrant <jats:styled-content style=\"fixed-case\">CD5<\/jats:styled-content> co\u2010expression, confirming cutaneous involvement by B\u2010<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Co\u2010existence of a GA\u2010like infiltrate and cutaneous B\u2010<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> raises the possibility that granulomatous inflammation occurs as a secondary response to dermal infiltration by leukemic cells. Because histopathologic findings can be subtle, knowledge of this association is essential to avoid overlooking the diagnosis. Regardless of whether histopathology reflects a reactive or primary phenomenon, documentation of cutaneous involvement by B\u2010<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> may serve as a rationale for specific treatment of the underlying B\u2010<jats:styled-content style=\"fixed-case\">CLL<\/jats:styled-content> in patients with skin lesions unresponsive to dermatologic therapy and for whom there is no other justification for leukemia\u2010targeted therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0560.2012.01967.x","type":"journal-article","created":{"date-parts":[[2012,7,25]],"date-time":"2012-07-25T11:41:48Z","timestamp":1343216508000},"page":"996-1003","source":"Crossref","is-referenced-by-count":9,"title":["Granuloma annulare\u2010like eruption associated with B\u2010cell chronic lymphocytic leukemia"],"prefix":"10.1111","volume":"39","author":[{"given":"Olayemi","family":"Sokumbi","sequence":"first","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence E.","family":"Gibson","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"},{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nneka I.","family":"Comfere","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"},{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margot S.","family":"Peters","sequence":"additional","affiliation":[{"name":"Department of Dermatology Mayo Clinic  Rochester MN USA"},{"name":"Department of Laboratory Medicine and Pathology Mayo Clinic  Rochester MN USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,25]]},"reference":[{"key":"e_1_2_5_2_1","volume-title":"SEER cancer statistics review, 1975\u20132007 [Internet]","author":"Altekruse SF","year":"2009"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(80)80181-2"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199608000-00009"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2004.05982.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1985.tb02359.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1977.tb14325.x"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1997.tb01127.x"},{"key":"e_1_2_5_9_1","first-page":"631","article-title":"Generalized granuloma annulare post autologous bone marrow transplantation in a Hodgkin's disease patient","volume":"14","author":"Nevo S","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2008.02730.x"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(94)70133-4"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-200302000-00012"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(84)70145-9"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1080\/1024533021000008164"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2008.12.047"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/10428190601137336"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4362.1990.tb02589.x"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.2004.023911"},{"key":"e_1_2_5_19_1","first-page":"50","article-title":"Chronic lymphocytic leukemia revealed by a granulomatous zosteriform eruption","volume":"10","author":"Trojjet S","year":"2012","journal-title":"Skinmed"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.2011.01811.x"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(97)70334-7"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2002.290303.x"},{"key":"e_1_2_5_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01709.x"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198802000-00002"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annder.2009.01.020"},{"key":"e_1_2_5_26_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1980.01640280077025"},{"key":"e_1_2_5_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2002.04880.x"},{"key":"e_1_2_5_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2006.02324.x"}],"container-title":["Journal of Cutaneous Pathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0560.2012.01967.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0560.2012.01967.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:37:35Z","timestamp":1700566655000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0560.2012.01967.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,25]]},"references-count":27,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1600-0560.2012.01967.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0560.2012.01967.x","archive":["Portico"],"relation":{},"ISSN":["0303-6987","1600-0560"],"issn-type":[{"value":"0303-6987","type":"print"},{"value":"1600-0560","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,25]]}}}