{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:46:47Z","timestamp":1700567207300},"reference-count":15,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T00:00:00Z","timestamp":1343433600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["J Cutan Pathol"],"published-print":{"date-parts":[[2012,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Epidermal malignancies developing in association with hematolymphoid malignancies are exceptional. Only one prior case of myeloid leukemia cutis with a cutaneous epidermal malignancy has been reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We report two cases; one occurred in association with squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) and another with basal cell carcinoma (<jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content>).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both patients were 83\u2010year\u2010old males without established histories of systemic hematopoietic disorders; one presented with an erythematous papule on the right upper back and the other with a nodule on the left wrist. One biopsy revealed nodular <jats:styled-content style=\"fixed-case\">BCC<\/jats:styled-content> with an associated perivascular myeloid leukemic infiltrate showing immunohistochemical positivity for <jats:styled-content style=\"fixed-case\">CD43<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">CD45<\/jats:styled-content>. The other biopsy showed <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> associated with a leukemic infiltrate in sheets with myeloid blasts, eosinophilic myelocytes and maturing myeloid precursors. The myeloid cells showed immunohistochemical expression of <jats:styled-content style=\"fixed-case\">CD43<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD68<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD33<\/jats:styled-content>, <jats:styled-content style=\"fixed-case\">CD117<\/jats:styled-content> and myeloperoxidase. Both patients had myeloblasts on peripheral blood smear. One patient declined further treatment and died of disease 5\u2009weeks after the initial biopsy. The other patient underwent chemotherapy and is alive after 6\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Although most inflammatory infiltrates associated with cutaneous epidermal malignancies are reactive, careful examination is necessary to exclude systemic hematopoietic disease, especially in elderly patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1600-0560.2012.01978.x","type":"journal-article","created":{"date-parts":[[2012,7,28]],"date-time":"2012-07-28T11:17:34Z","timestamp":1343474254000},"page":"971-976","source":"Crossref","is-referenced-by-count":1,"title":["Leukemia cutis in association with cutaneous epidermal malignancies"],"prefix":"10.1111","volume":"39","author":[{"given":"Seong","family":"Ra","sequence":"first","affiliation":[{"name":"San Diego Pathologists Medical Group  San Diego CA USA"},{"name":"Department of Pathology UCLA Medical Center  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Albert","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Pathology UCLA Medical Center  Los Angeles CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Doug","family":"Ellison","sequence":"additional","affiliation":[{"name":"San Diego Pathologists Medical Group  San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Koperski","sequence":"additional","affiliation":[{"name":"Dermatologists Medical Group Encinitas  San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Bonilla","sequence":"additional","affiliation":[{"name":"Torrey Pines Dermatology  San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruce","family":"Robbins","sequence":"additional","affiliation":[{"name":"San Diego Pathologists Medical Group  San Diego CA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2012,7,28]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2003.29194.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0560.1998.tb01709.x"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.5070\/D333J4H764"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0560.2000.027006271.x"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0303-6987.2004.00204.x"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2001.110875"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03232.x"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2005.07029.x"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000372-199406000-00005"},{"key":"e_1_2_5_11_1","unstructured":"Howlader N Noone AM Krapcho M et al. 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