{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T11:31:27Z","timestamp":1699702287903},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"vor","delay-in-days":11316,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Journal of Haematology"],"published-print":{"date-parts":[[1978,5]]},"abstract":"<jats:p>The bone marrow cells of a patient with congenital dyserythropoietic anaemia, type II, were incubated with <jats:sup>3<\/jats:sup>H\u2010thymidine, <jats:sup>3<\/jats:sup>H\u2010uridine or <jats:sup>3<\/jats:sup>H\u2010leucine for 1 h and studied using the technique of electron microscope autoradiography. Several of the erythroblasts which either displayed the characteristic subsurface double membranes or showed various non\u2010specific abnormalities of the nuclear membrane were found to be actively engaged in DNA, RNA and protein synthesis. Both members of some pairs of erythroblasts which were joined together by a spindle bridge were found to be engaged in DNA synthesis, indicating that some spindle bridges persist for a period longer than the duration of the G<jats:sub>1<\/jats:sub> phase. A small proportion of mononucleate and binucleate late (non\u2010dividing) erythroblasts showed a marked depression or arrest of protein synthesis and some or all of such cells were presumably destined to be phago\u2010cytosed by the bone marrow macrophages.<\/jats:p>","DOI":"10.1111\/j.1600-0609.1978.tb02479.x","type":"journal-article","created":{"date-parts":[[2010,8,3]],"date-time":"2010-08-03T09:28:15Z","timestamp":1280827695000},"page":"429-439","source":"Crossref","is-referenced-by-count":6,"title":["Electron Microscope Autoradiographic Studies of the Erythroblasts of a Case of Congenital Dyserythropoietic Anaemia, Type II"],"prefix":"10.1111","volume":"20","author":[{"given":"S. N.","family":"Wickramasinghe","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T. E.","family":"Parry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeleine","family":"Hughes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,24]]},"reference":[{"key":"e_1_2_1_2_1","first-page":"23","article-title":"Anomalies ultrastructurales des \u00e9rythroblastes et des \u00e9rythrocytes dans six cas de dys\u00e9rythrop\u00f6i\u00e9se cong\u00e9nitale","volume":"13","author":"Breton\u2010Gorius J","year":"1973","journal-title":"Nouv Rev Fr Hematol"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.25.7.561"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1969.tb05660.x"},{"key":"e_1_2_1_5_1","unstructured":"HeimpelH Forteza\u2010VilaJ&QueisserW(1970)Morphological aberrations of the erythroblasts in congenital dyserythropoietic anemia type I and II.Proc 13th Cong Int Soc Haematol(abstract) Munich p391."},{"key":"e_1_2_1_6_1","first-page":"103","article-title":"Congenital dyserythropoietic anemia with karyorrhexis and multinuclearity of erythroblasts","volume":"34","author":"Heimpel H","year":"1968","journal-title":"Helv Med Acta"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720196.ch11"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02154294"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720196.ch13"},{"key":"e_1_2_1_10_1","first-page":"21","volume-title":"Dys\u2010erythropoiesis","author":"Wickramasinghe S N","year":"1977"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000207854"},{"key":"e_1_2_1_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000208834"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb01053.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1973.tb01721.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1182\/blood.V39.1.23.23","article-title":"Congenital dyserythropoietic anemia type II: ultra\u2010structural and autoradiographic studies of blood and bone marrow","volume":"39","author":"Wong K Y","year":"1972","journal-title":"Blood"}],"container-title":["Scandinavian Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.1978.tb02479.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.1978.tb02479.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T12:25:33Z","timestamp":1699446333000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.1978.tb02479.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1978,5]]},"references-count":14,"journal-issue":{"issue":"5","published-print":{"date-parts":[[1978,5]]}},"alternative-id":["10.1111\/j.1600-0609.1978.tb02479.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.1978.tb02479.x","archive":["Portico"],"relation":{},"ISSN":["0036-553X"],"issn-type":[{"value":"0036-553X","type":"print"}],"subject":[],"published":{"date-parts":[[1978,5]]}}}