{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T06:48:13Z","timestamp":1699512493101},"reference-count":14,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"vor","delay-in-days":10067,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Journal of Haematology"],"published-print":{"date-parts":[[1981,10]]},"abstract":"<jats:p>The usefulness of the epinephrine stimulation test in detecting granulocytic hypersplenism is evaluated. In 8 hypersplenic patients, an increment of the granulocyte count of 170 % over baseline values was found, compared to 38 % (P &lt; 0.001) in normal subjects and 44 % (P &lt; 0.002) in patients neutropenic from other causes. No overlap of individual test results was found among the hypersplenic and the control groups. Epinephrine test discriminates between neutropenia from hypersplenism and neutropenia from other causes. Furthermore, this test is found to be a valuable adjunct to the hydrocortisone stimulation test in kinetic evaluation of neutropenia from any cause.<\/jats:p>","DOI":"10.1111\/j.1600-0609.1981.tb00477.x","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T21:10:28Z","timestamp":1280956228000},"page":"225-230","source":"Crossref","is-referenced-by-count":9,"title":["Granulocyte Demargination by Epinephrine in Evaluation of Hypersplenic States"],"prefix":"10.1111","volume":"27","author":[{"given":"Andreas","family":"Schaffner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jorg","family":"Fehr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI104230"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI106657"},{"key":"e_1_2_1_4_1","first-page":"508","article-title":"Correlation of splenomegaly and abnormal neutrophil pooling (margination)","volume":"92","author":"Brubaker L H","year":"1978","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_5_1","first-page":"434","volume-title":"Practical haematology","author":"Dacie J V","year":"1975"},{"key":"e_1_2_1_6_1","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1182\/blood.V52.5.1021.1021","article-title":"Postmitotic marrow neutrophils and neutrophil mobilization in man: role of the spleen","volume":"52","author":"Deubelbeiss K A","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(79)90554-0"},{"key":"e_1_2_1_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830070409"},{"key":"e_1_2_1_9_1","doi-asserted-by":"crossref","first-page":"629","DOI":"10.1182\/blood.V47.4.629.629","article-title":"Mechanism of dilutional anaemia in massive splenomegaly","volume":"47","author":"Hess C E","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1974.tb06768.x"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(80)90420-9"},{"key":"e_1_2_1_12_1","first-page":"614","article-title":"Marginal neutrophil pool size in normal subjects and neutropenic patients as measured by epinephrine infusion","volume":"88","author":"Joyce R A","year":"1976","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1972.tb00952.x"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-85-4-437"},{"key":"e_1_2_1_15_1","first-page":"24","article-title":"Hypersplenism","volume":"118","author":"Ries C A","year":"1973","journal-title":"Calif Med"}],"container-title":["Scandinavian Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.1981.tb00477.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.1981.tb00477.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T16:58:39Z","timestamp":1699462719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.1981.tb00477.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,10]]},"references-count":14,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,10]]}},"alternative-id":["10.1111\/j.1600-0609.1981.tb00477.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.1981.tb00477.x","archive":["Portico"],"relation":{},"ISSN":["0036-553X"],"issn-type":[{"value":"0036-553X","type":"print"}],"subject":[],"published":{"date-parts":[[1981,10]]}}}