{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,4]],"date-time":"2025-09-04T13:22:14Z","timestamp":1756992134322},"reference-count":32,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"vor","delay-in-days":10159,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Journal of Haematology"],"published-print":{"date-parts":[[1981,7]]},"abstract":"<jats:p>The serum concentration of beta<jats:sub>2<\/jats:sub>\u2010microglobulin (beta<jats:sub>2<\/jats:sub>\u2010m) was measured in 69 patients with acute or chronic lympho\u2010 and myeloproliferative disorders. Serum beta<jats:sub>2<\/jats:sub>\u2010m was found significantly increased in 12 out of 14 patients with chronic lymphatic leukaemia. The serum concentration was proportional to the estimated lymphatic infiltration of tissues but inversely related to the number of circulating lymphocytes. Cytostatic treatment was followed by a decrease in serum beta<jats:sub>2<\/jats:sub>\u2010m, but normalization of the serum concentration was not observed. 11 patients with chronic granulocytic leukaemia all had significantly elevated serum concentrations of beta<jats:sub>2<\/jats:sub>\u2010m and increased serum concentrations were also found in patients with acute leukaemias. Thus, 12 out of 25 patients with acute myeloid leukaemia and all of 5 patients with acute myelomonocytic leukaemia as well as 4 out of 5 patients with acute lymphatic leukaemia had increased serum beta<jats:sub>2<\/jats:sub>\u2010m levels. In acute leukaemia no correlation could be demonstrated between the blood lymphocyte concentration and serum beta<jats:sub>2<\/jats:sub>\u2010m. Also no significant changes in serum beta<jats:sub>2<\/jats:sub>\u2010m were found in either remission or relapse of the acute leukaemia. It is concluded that serum beta<jats:sub>2<\/jats:sub>\u2010m in patients with chronic leukaemia may reflect the total amount or turn\u2010over of leukaemic cells in the body and that repeated determinations of serum beta<jats:sub>2<\/jats:sub>\u2010m in these patients might be useful as an estimate of the residual leukaemic cell mass after therapy. Apart from this the determination of serum beta<jats:sub>2<\/jats:sub>\u2010m seems to be of little, if any, clinical use in leukaemia.<\/jats:p>","DOI":"10.1111\/j.1600-0609.1981.tb01401.x","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T20:10:30Z","timestamp":1280952630000},"page":"275-285","source":"Crossref","is-referenced-by-count":24,"title":["Serum Beta<sub>2<\/sub>\u2010Microglobulin in Acute and Chronic Leukaemia"],"prefix":"10.1111","volume":"25","author":[{"given":"J\u00f8rgen","family":"Ellegaard","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carl Erik","family":"Mogensen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Knud","family":"Kragballe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2964(79)90155-5"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1976.tb03563.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"4095","DOI":"10.1016\/S0021-9258(18)93284-9","article-title":"Isolation and properties of a low molecular weight beta2\u2010globulin occurring in human biological fluids","volume":"243","author":"Berggaard I.","year":"1968","journal-title":"J Biol Chem"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"407","DOI":"10.4049\/jimmunol.109.2.407","article-title":"Synthesis of beta2\u2010microglobulin by stimulated lymphocytes","volume":"109","author":"Bernier G. 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