{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T03:29:11Z","timestamp":1789874951839,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"vor","delay-in-days":10281,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Journal of Haematology"],"published-print":{"date-parts":[[1981,3]]},"abstract":"<jats:p>Whole blood glutathione peroxidase was found significantly increased relative to controls in a group of 21 black patients with sickle cell anaemia. One control group consisted of 15 normal black subjects. A second control group, consisting of 21 black patients with various abnormal haemoglobins including a\u2010thalassaemia, also showed a tendency to enhanced glutathione peroxidase activity, confirming previous reports that elevated glutathione peroxidase levels are secondary to a variety of haemolytic conditions, rather than typical of sickle cell anaemia.<\/jats:p>","DOI":"10.1111\/j.1600-0609.1981.tb01644.x","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T21:23:24Z","timestamp":1280957004000},"page":"177-181","source":"Crossref","is-referenced-by-count":8,"title":["Glutathione Peroxidase Activity in Whole Blood of Patients with Sickle Cell Anaemia"],"prefix":"10.1111","volume":"26","author":[{"given":"Carola Ponzetto","family":"Zimmerman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clayton","family":"Natta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2009,4,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1182\/blood.V46.1.103.103","article-title":"Ethnic variation in red cell glutathione peroxidase activity","volume":"46","author":"Beutler E.","year":"1975","journal-title":"Blood"},{"key":"e_1_2_1_3_1","first-page":"71","volume-title":"Red cell metabolism. A manual of biochemical methods","author":"Beutler E.","year":"1975"},{"key":"e_1_2_1_4_1","doi-asserted-by":"crossref","first-page":"467","DOI":"10.1182\/blood.V49.3.467.467","article-title":"Glucose\u20106\u2010phosphate dehydrogenase deficiency and red cell glutathione peroxidase","volume":"49","author":"Beutler E.","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_5_1","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1182\/blood.V50.4.647.647","article-title":"Increased glutathione peroxidase activity in \u03b1\u2010thalassemia","volume":"50","author":"Beutler E.","year":"1977","journal-title":"Blood"},{"key":"e_1_2_1_6_1","first-page":"95","article-title":"Vit E level and glutathione peroxidase activity in sickle cell anemia","volume":"52","author":"Chiu D.","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/103.4.618"},{"key":"e_1_2_1_8_1","first-page":"2090","article-title":"Mechanism of action of selenium and vit E in protection of biological membranes","volume":"34","author":"Combs G F","year":"1975","journal-title":"Fed Proc"},{"key":"e_1_2_1_9_1","first-page":"444","article-title":"An improved coupled test procedure for glutathione peroxidase (EC 1.11.1.9) in blood","volume":"12","author":"Gunzler W A","year":"1974","journal-title":"Z Klin Chem Klin Biochem"},{"key":"e_1_2_1_10_1","first-page":"700","article-title":"Microchromatography of hemoglobins III. A simplified procedure for the determination of Hb A2","volume":"86","author":"Huisman T H J","year":"1975","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_11_1","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1182\/blood.V51.6.1163.1163","article-title":"Failure of the \u03b1\u2010thalassemia gene to decrease the severity of sickle cell anemia","volume":"51","author":"Natta C.","year":"1978","journal-title":"Blood"},{"key":"e_1_2_1_12_1","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/ajcn\/32.7.1359","article-title":"Plasma level of tocopherol in sickle cell anemia subjects","volume":"32","author":"Natta C.","year":"1979","journal-title":"Am J Nutr"},{"key":"e_1_2_1_13_1","first-page":"158","article-title":"Studies on the quantitative and qualitative characterization of erythrocyte glutathione peroxidase","volume":"70","author":"Paglia D E","year":"1967","journal-title":"J Lab Clin Med"},{"key":"e_1_2_1_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb01111.x"},{"key":"e_1_2_1_15_1","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1182\/blood.V47.3.495.495","article-title":"Lipid membrane peroxidation in \u03b2\u2010thalassemia major","volume":"47","author":"Rachmilewitz E A","year":"1976","journal-title":"Blood"},{"key":"e_1_2_1_16_1","first-page":"413","article-title":"Studies on abnormal hemoglobins I. Their demonstration in sickle cell anemia and other hematological disorders by means of alkali denaturation","volume":"6","author":"Singer K.","year":"1951","journal-title":"Blood"}],"container-title":["Scandinavian Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.1981.tb01644.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.1981.tb01644.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T13:43:54Z","timestamp":1699451034000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.1981.tb01644.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,3]]},"references-count":15,"journal-issue":{"issue":"3","published-print":{"date-parts":[[1981,3]]}},"alternative-id":["10.1111\/j.1600-0609.1981.tb01644.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.1981.tb01644.x","archive":["Portico"],"relation":{},"ISSN":["0036-553X"],"issn-type":[{"value":"0036-553X","type":"print"}],"subject":[],"published":{"date-parts":[[1981,3]]}}}