{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T04:56:48Z","timestamp":1761541008118},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"vor","delay-in-days":10250,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Scandinavian Journal of Haematology"],"published-print":{"date-parts":[[1981,4]]},"abstract":"<jats:p>There are 3 varieties of idiopathic thrombocytopenic purpura (ITP) in children: the acute, the chronic and the recurrent forms. We have tested the platelets from 80 children with these forms of ITP by an immunofluorescence test. Platelet\u2010bound immunoglobulins were detected in 19\/22 acute, 41\/48 chronic and 5\/10 recurrent cases of ITP, i.e. in 65 of a total of 80 cases. A significance differences between acute and chronic ITP was found in the observation that only IgM was bound to the platelets of 7\/16 patients with acute ITP.<\/jats:p><jats:p>In all cases of chronic ITP with a positive direct immunofluorescence test, IgG was present on the platelet membrane. It is assumed because some patients with chronic ITP do not have elavated platelet\u2010bound immunoglobulins, and show refractoriness to immunosuppressive therapy, that in these patients the disorder is not of a humoral autoimmune nature.<\/jats:p>","DOI":"10.1111\/j.1600-0609.1981.tb01663.x","type":"journal-article","created":{"date-parts":[[2010,8,4]],"date-time":"2010-08-04T23:35:45Z","timestamp":1280964945000},"page":"285-291","source":"Crossref","is-referenced-by-count":11,"title":["Idiopathic Thrombocytopenic Purpura in Children; Detection of Platelet Autoantibodies by Immunofluorescence"],"prefix":"10.1111","volume":"26","author":[{"given":"E. F. van","family":"Leeuwen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. E. G. Kr.","family":"von dem Borne","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. Plasvan","family":"van der Dalen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C. P.","family":"Engelfriet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2009,4,24]]},"reference":[{"key":"e_1_2_1_2_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196606022742207"},{"key":"e_1_2_1_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1980.tb07151.x"},{"key":"e_1_2_1_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1978.tb01089.x"},{"key":"e_1_2_1_5_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197901183000302"},{"key":"e_1_2_1_6_1","first-page":"6","article-title":"Cellular immunity to autologous platelets and serum\u2010blocking factors in idiopathic thrombocytopenic purpura","volume":"1","author":"Clancy R.","year":"1977","journal-title":"Lancet"},{"key":"e_1_2_1_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197501302920503"},{"key":"e_1_2_1_8_1","first-page":"1","article-title":"Demonstration of a thrombocytopenic factor in the blood of patients with thrombocytopenic purpura","volume":"38","author":"Harrington WJ","year":"1951","journal-title":"J Clin Med"},{"key":"e_1_2_1_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1980.tb01842.x"},{"key":"e_1_2_1_10_1","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1182\/blood.V53.1.73.73","article-title":"The direct assay for platelet\u2010associated IgG (PAIgG): Lack of association between antibody level and platelet size","volume":"53","author":"Kelton JG","year":"1979","journal-title":"Blood"},{"key":"e_1_2_1_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(79)80823-9"},{"key":"e_1_2_1_12_1","first-page":"49","article-title":"The occurrence of circulating immune complexes and viral antigens in idiopathic thrombocytopenic purpura","volume":"28","author":"Lurhuma AZ","year":"1977","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(66)80218-4"},{"issue":"3","key":"e_1_2_1_14_1","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1055\/s-0028-1086136","article-title":"Idiopathic thrombocytopenic purpura in children","volume":"3","author":"Lusher JM","year":"1977","journal-title":"Semin Thromb Hemostas"},{"key":"e_1_2_1_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1978.tb02947.x"},{"key":"e_1_2_1_16_1","first-page":"323","article-title":"Interaction between human blood platelets, viruses and antibodies. IV. Post\u2010rubella thrombocytopenic purpura and platelet aggregation by rubella antigen\u2010antibody interactions","volume":"4","author":"Myllyl\u00e4 GA","year":"1969","journal-title":"Clin Exp Immunol"},{"key":"e_1_2_1_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.16.1.70"},{"key":"e_1_2_1_18_1","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1182\/blood.V40.6.856.856","article-title":"Cellular immunity to platelets in idiopathic thrombocytopenic purpura","volume":"40","author":"Wybran J.","year":"1972","journal-title":"Blood"}],"container-title":["Scandinavian Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.1981.tb01663.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.1981.tb01663.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,8]],"date-time":"2023-11-08T14:09:24Z","timestamp":1699452564000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.1981.tb01663.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,4]]},"references-count":17,"journal-issue":{"issue":"4","published-print":{"date-parts":[[1981,4]]}},"alternative-id":["10.1111\/j.1600-0609.1981.tb01663.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.1981.tb01663.x","archive":["Portico"],"relation":{},"ISSN":["0036-553X"],"issn-type":[{"value":"0036-553X","type":"print"}],"subject":[],"published":{"date-parts":[[1981,4]]}}}