{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T06:57:32Z","timestamp":1763017052192},"reference-count":55,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T00:00:00Z","timestamp":1240531200000},"content-version":"vor","delay-in-days":4223,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[1997,10]]},"abstract":"<jats:p><jats:bold>Abstract: <\/jats:bold> We investigated the cytokine profile and peak levels of interleukin (IL) \u20106, IL\u20108, IL\u201010 and tumour necrosis factor (TNF) \u2010\u03b1 levels in 42 patients after allogeneic bone marrow transplantation (BMT). Eleven of them developed veno\u2010occlusive disease (VOD) of the liver. Fourteen patients had moderate\u2010to\u2010severe acute graft\u2010versus\u2010host disease (aGvHD), 10 isolated bacteraemia and 7 had no major complication. Those who developed severe VOD (<jats:italic>n<\/jats:italic> = 6) showed a short, very high IL\u20108 peak (median: 6632 pg\/ml, range: 5546 \u2013 10,000 vs. 280 pg\/ml, 0 \u2013 2042 in controls, <jats:italic>p<\/jats:italic> &lt; 0.01) 1 \u2013 4 d after diagnosis of the liver disease. Five of these patients had high peak levels of IL\u20106. Five patients with mild VOD showed a lower increase in the cytokines tested. Bilirubin levels, at day of IL\u20108 peak, did not differ statistically between mild and severe VOD. The highest levels of IL\u201010 were found in those with aGvHD. IL\u20108 levels were also increased, but not to the same extent as in patients with severe VOD (<jats:italic>p<\/jats:italic> = 0.01 vs. VOD). In patients with bacteraemia, very high levels of IL\u20106 were seen. In patients without major complications, the levels of cytokines were low. In conclusion, high levels of IL\u20108 occurred in severe VOD of the liver, which may be of value to determine prognosis.<\/jats:p>","DOI":"10.1111\/j.1600-0609.1997.tb00985.x","type":"journal-article","created":{"date-parts":[[2010,7,18]],"date-time":"2010-07-18T08:25:55Z","timestamp":1279441555000},"page":"254-262","source":"Crossref","is-referenced-by-count":30,"title":["Serum levels of cytokines after bone marrow transplantation: increased IL\u20108 levels during severe veno\u2010occlusive disease of the 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