{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,11]],"date-time":"2026-11-11T02:50:32Z","timestamp":1794365432288,"version":"4.9.0"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract:<\/jats:title><jats:p><jats:bold>Objective:\u2002<\/jats:bold> Live\u2010attenuated varicella vaccine is effective and safe in immunocompetent children. In this study, we assess the immunogenicity and adverse events following varicella vaccination in immunosuppressed cancer children.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Varicella\u2010zoster virus (VZV)\u2010seronegative cancer children received two doses of live\u2010attenuated VZV vaccine (Varilrix<jats:sup>\u00ae<\/jats:sup>) in a span of 3\u2003months. Patients with acute lymphoblastic leukaemia (ALL) were in the maintenance phase of chemotherapy, whereas those with solid tumours joined the study around 3\u20136\u2003months from treatment discontinuation. VZV\u2010specific cellular and humoral immune responses were measured before and after VZV vaccination.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> The median (range) age of the 17 patients was 4.4\u2003yr (2.0\u201314.5). Thirteen had ALL, one had myelodysplastic syndrome and three had solid tumours. Following vaccination, the VZV\u2010specific stimulation index (SI) increased from 1.7 (0.9\u20132.9) to 17.9 (5.9\u201336.0) (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Similarly, SI to phytohaemagglutinin mitogen increased from 1136 (499\u20131930) to 1714 (848\u20132518) (<jats:italic>P<\/jats:italic>\u2003=\u20030.028). There were also significant increases in CD4+ cells and CD4\u2003:\u2003CD8 ratio as well as a reduction in CD16\/56+ cells in peripheral blood lymphocytes. Seroconversion rate to VZV was 19% after one dose and increased to 94% after the second dose of VZV vaccine. Serum VZV\u2010specific IgG concentrations also increased significantly following two doses when compared with one dose of VZV vaccine (<jats:italic>P<\/jats:italic>\u2003=\u20030.0004). One subject developed possibly vaccine\u2010related chickenpox with self\u2010limiting hepatitis at 5\u2003wk following vaccination. None of the patients developed herpes\u2010zoster at a median (range) follow\u2010up of 27.5\u2003months (24.0\u201330.0).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Non\u2010immune cancer children can be effectively vaccinated against chickenpox at the defined period. However, the safety of chickenpox vaccine in these immunosuppressed children needs to be further studied.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2004.00216.x","type":"journal-article","created":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T15:43:58Z","timestamp":1080834238000},"page":"353-357","source":"Crossref","is-referenced-by-count":44,"title":["Immunogenicity of a two\u2010dose regime of varicella vaccine in children with cancers"],"prefix":"10.1111","volume":"72","author":[{"given":"Ting\u2010Fan","family":"Leung","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Kong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily C. W.","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul K. S.","family":"Chan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi\u2010Wai","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond P. O.","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ki\u2010Wai","family":"Chik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2004,4]]},"reference":[{"key":"e_1_2_14_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1994.03510290057037"},{"key":"e_1_2_14_3_2","doi-asserted-by":"publisher","DOI":"10.1017\/S0950268800050007"},{"key":"e_1_2_14_4_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.287.5.606"},{"key":"e_1_2_14_5_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.80.4.465"},{"key":"e_1_2_14_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1423-0410.1997.7330167.x"},{"issue":"4","key":"e_1_2_14_7_2","first-page":"69","article-title":"Active immunization against varicella of children with acute leukaemia or other malignancies on maintenance chemotherapy","volume":"61","author":"Haas RJ","year":"1985","journal-title":"Postgrad Med J"},{"key":"e_1_2_14_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/174.Supplement_3.S320"},{"key":"e_1_2_14_9_2","doi-asserted-by":"crossref","first-page":"636","DOI":"10.4049\/jimmunol.142.2.636","article-title":"T lymphocyte cytotoxicity with natural varicella\u2010zoster virus infection and after immunization with live attenuated varicella vaccine","volume":"142","author":"Diaz PS","year":"1989","journal-title":"J Immunol"},{"key":"e_1_2_14_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/166.Supplement_1.S35"},{"key":"e_1_2_14_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0264-410X(98)00249-7"},{"key":"e_1_2_14_12_2","doi-asserted-by":"crossref","first-page":"2799","DOI":"10.4049\/jimmunol.139.8.2799","article-title":"Cooperation between CD16 (Leu\u201011b)+ NK cells and HLA\u2010DR+ cells in natural killing of herpesvirus\u2010infected fibroblasts","volume":"139","author":"Oh SH","year":"1987","journal-title":"J Immunol"},{"key":"e_1_2_14_13_2","doi-asserted-by":"publisher","DOI":"10.1089\/vim.1996.9.241"},{"key":"e_1_2_14_14_2","doi-asserted-by":"crossref","first-page":"3022","DOI":"10.1182\/blood.V88.8.3022.bloodjournal8883022","article-title":"Identification of an unusual Fc gamma receptor IIIa (CD16) on natural killer cells in a patient with recurrent infections","volume":"88","author":"De Vries E","year":"1996","journal-title":"Blood"},{"key":"e_1_2_14_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198906293202605"},{"key":"e_1_2_14_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-3955(16)36911-5"},{"key":"e_1_2_14_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/161.4.661"},{"key":"e_1_2_14_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702119"},{"key":"e_1_2_14_19_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013441"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2004.00216.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2004.00216.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2004.00216.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T13:12:04Z","timestamp":1697202724000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2004.00216.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":18,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.1600-0609.2004.00216.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2004.00216.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}