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A morphological, immunophenotypical and cytogenetic study has been performed to characterize the case and in order to identify the origin of two disorders. After the failure of the conventional therapy, the patient was treated with Imatinib with a complete hematological and cytogenetic response and a marked reduction of bone marrow fibrosis.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2004.00222.x","type":"journal-article","created":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T15:43:58Z","timestamp":1080834238000},"page":"361-365","source":"Crossref","is-referenced-by-count":1,"title":["Co\u2010existence of Philadelphia chromosome positive acute megakaryoblastic and B\u2010lymphoblastic mixed blast crisis of chronic myeloid leukemia with chronic lymphocytic leukemia"],"prefix":"10.1111","volume":"72","author":[{"given":"Simona","family":"Colla","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabriella","family":"Sammarelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica","family":"Crugnola","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefano","family":"Ascani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Sabbatini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabrina","family":"Bonomini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Magda","family":"Hojden","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa","family":"Craviotto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabel De","family":"Celis","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesca","family":"Morandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cecilia","family":"Caramatti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vittorio","family":"Rizzoli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicola","family":"Giuliani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197508)36:2<576::AID-CNCR2820360237>3.0.CO;2-G"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199604000-00016"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.01638.x"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2402490"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000063435"},{"key":"e_1_2_4_7_2","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1182\/blood.V83.5.1373.1373","article-title":"Identification of Philadelphia\u2010negative granulocyte\u2010macrophage colony\u2010forming units generated by stroma\u2010adherent cells from chronic myelogenous leukemia patients","volume":"83","author":"Carlo\u2010Stella C","year":"1994","journal-title":"Blood"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02982695"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.10.3547"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2004.00222.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2004.00222.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2004.00222.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T13:12:15Z","timestamp":1697202735000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2004.00222.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":8,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.1600-0609.2004.00222.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2004.00222.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}