{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T10:26:17Z","timestamp":1760264777046},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2004,5]]},"abstract":"<jats:title>Abstract:<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> The purpose of this study was to evaluate serum leptin levels in idiopathic thrombocytopenic purpura (ITP), in order to determine the influence of leptin on the pathogenesis of ITP.<\/jats:p><jats:p><jats:bold>Subjects and methods:\u2002<\/jats:bold> Forty\u2010six untreated patients with chronic ITP were compared with 40 healthy people of similar age, sex and body mass index (BMI). Serum leptin levels (ng\/mL) were measured by enzyme\u2010linked immunosorbent assay (ELISA).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> We found that the mean serum leptin levels in patients with ITP (22.11\u2003\u00b1\u200315.84\u2003ng\/mL) were significantly (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) higher than that in healthy control volunteers (5.44\u2003\u00b1\u20034.84\u2003ng\/mL). Furthermore, serum leptin levels in patients with ITP were inversely related (<jats:italic>r<\/jats:italic>\u2003=\u2003\u22120.86, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) to the platelet counts and positively related to the platelet\u2010associated IgG (PAIgG) levels (<jats:italic>r<\/jats:italic>\u2003=\u20030.7, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). The levels of PAIgG and platelet counts were significantly different between leptin\u2010positive (level greater than mean\u2003\u00b1\u20032 SD control value) and leptin\u2010negative patients.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> These findings suggest that leptin might play an important role in the pathogenesis of ITP.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2004.00231.x","type":"journal-article","created":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T15:43:58Z","timestamp":1080834238000},"page":"348-352","source":"Crossref","is-referenced-by-count":10,"title":["Serum leptin levels in patients with idiopathic thrombocytopenic purpura"],"prefix":"10.1111","volume":"72","author":[{"given":"Mei","family":"Zhan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Renchi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong Chao","family":"Han","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,4]]},"reference":[{"key":"e_1_2_12_2_2","first-page":"18","article-title":"Pathogenesis and management of chronic idiopathic thrombocytopenic purpura: an update","volume":"71","author":"Yang R","year":"2000","journal-title":"Int J Hematol"},{"key":"e_1_2_12_3_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.59.4.243"},{"key":"e_1_2_12_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-6147(00)01767-3"},{"key":"e_1_2_12_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/nm0997-1029"},{"key":"e_1_2_12_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/s001250050838"},{"key":"e_1_2_12_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2249.2003.02190.x"},{"key":"e_1_2_12_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1471-4906(02)02188-9"},{"key":"e_1_2_12_9_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200316721"},{"key":"e_1_2_12_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/1521-4141(200105)31:5<1324::AID-IMMU1324>3.0.CO;2-Y"},{"key":"e_1_2_12_11_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.166.10.5909"},{"key":"e_1_2_12_12_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0216-9"},{"key":"e_1_2_12_13_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.51.5.1356"},{"key":"e_1_2_12_14_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2003.00032.x"},{"key":"e_1_2_12_15_2","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1182\/blood.V100.5.1774.h81702001774_1774_1779","article-title":"Expression patterns of Th1 and Th2 cytokine genes in childhood idiopathic thrombocytopenic purpura (ITP) at presentation and their modulation by intravenous immunoglobulin G (IVIg) treatment: their role in prognosis","volume":"100","author":"Mouzaki A","year":"2002","journal-title":"Blood"},{"key":"e_1_2_12_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(95)80068-9"},{"key":"e_1_2_12_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0952-7915(97)80192-6"},{"key":"e_1_2_12_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/1529-0131(199908)42:8<1644::AID-ANR12>3.0.CO;2-L"},{"key":"e_1_2_12_19_2","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(96)80606-2"},{"key":"e_1_2_12_20_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.07.040189.001045"},{"key":"e_1_2_12_21_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.12.040194.001303"},{"key":"e_1_2_12_22_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1651-2227.1998.tb01237.x"},{"key":"e_1_2_12_23_2","doi-asserted-by":"publisher","DOI":"10.1038\/372425a0"},{"key":"e_1_2_12_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)06348-4"},{"key":"e_1_2_12_25_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.92.15.6957"},{"key":"e_1_2_12_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90445-X"},{"key":"e_1_2_12_27_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.physiol.62.1.413"},{"key":"e_1_2_12_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-5793(95)00977-H"},{"key":"e_1_2_12_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(95)90151-5"},{"key":"e_1_2_12_30_2","doi-asserted-by":"publisher","DOI":"10.1038\/29795"},{"key":"e_1_2_12_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.040561297"},{"key":"e_1_2_12_32_2","doi-asserted-by":"crossref","first-page":"4579","DOI":"10.1182\/blood.V88.12.4579.bloodjournal88124579","article-title":"Characterization of autoantigenic epitopes on platelet glycoprotein IIb\/IIIa using random peptide libraries","volume":"88","author":"Bowditch RD","year":"1996","journal-title":"Blood"},{"key":"e_1_2_12_33_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4238"},{"key":"e_1_2_12_34_2","doi-asserted-by":"publisher","DOI":"10.1038\/oby.2003.36"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2004.00231.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2004.00231.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2004.00231.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T13:12:06Z","timestamp":1697202726000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2004.00231.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2004,5]]}},"alternative-id":["10.1111\/j.1600-0609.2004.00231.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2004.00231.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}