{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T15:44:58Z","timestamp":1759333498020},"reference-count":24,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2004,7,9]],"date-time":"2004-07-09T00:00:00Z","timestamp":1089331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2004,8]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Here we present a 40\u2010yr\u2010old male patient with an aggressive B\u2010cell lymphoma, who presented 2\u2003yr earlier with polyarthritis, and was responsive to steroids and oral methotrexate. Thereafter he developed skin and lung lesions which on biopsy consisted of mixed \u2018inflammatory\u2019 infiltrates with granulomatous vasculitis. A diagnosis of seronegative Wegener's granulomatosis was made and the patient received a combination of prednisone and cyclophosphamide with clinical improvement and clearance of the radiological lesions in the lungs. The patient was now completely asymptomatic for 1\u2003yr, but then generalized lymphadenopathy appeared, which was shown by histopathology to be large B\u2010cell lymphoma, also involving the bone marrow. Despite intensive chemotherapy, his disease could not be controlled because of primary chemoresistance, which was perhaps in some way related to exposure to the suboptimal doses of chemotherapy given during the \u2018inflammatory\u2019 period before the diagnosis of lymphoma was established. This case illustrates the occasional difficulty in distinguishing between extranodal lymphoproliferative diseases and autoimmune disorders especially when clonality cannot be proved. It also shows the possible risk of \u2018masking\u2019 a true lymphoma by treating non\u2010malignant diseases with immunosuppressive agents, which may eventually contribute to the development of chemoresistant lymphoma.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2004.00262.x","type":"journal-article","created":{"date-parts":[[2004,7,9]],"date-time":"2004-07-09T12:10:07Z","timestamp":1089375007000},"page":"134-138","source":"Crossref","is-referenced-by-count":12,"title":["Rapidly progressive diffuse large B\u2010cell lymphoma with initial clinical presentation mimicking seronegative Wegener's granulomatosis"],"prefix":"10.1111","volume":"73","author":[{"given":"Yossi","family":"Cohen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gail","family":"Amir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ginette","family":"Schibi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ninette","family":"Amariglio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron","family":"Polliack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,7,9]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03348976"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00296-002-0229-4"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199909000-00006"},{"key":"e_1_2_4_5_2","unstructured":"FauciSA.The vasculitic syndromes. 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