{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,4]],"date-time":"2025-04-04T02:26:33Z","timestamp":1743733593940},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T00:00:00Z","timestamp":1096502400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2004,11]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>  <jats:italic>Objectives<\/jats:italic>:\u2002We describe a rare case of adult T\u2010cell leukemia (ATL) presenting with dry mouth and swelling of bilateral parotid and submandibular glands. The unusual involvement of these exocrine glands by malignant cells prompted us to conduct a detail characterization of these infiltrating and circulating leukemic T cells, which may provide insight to the pathogenesis of exocrine involvement in ATL. <jats:italic>Methods<\/jats:italic>:\u2002Immunophenotyping of peripheral ATL cells and microscopic examinations of various organs prepared by autopsy were performed. Analysis of the repertoire of T\u2010cell receptor (TCR) of parotid gland\u2010infiltrating ATL cells using molecular and immunohistochemical examinations were also performed. <jats:italic>Results<\/jats:italic>:\u2002Microscopic examinations of various organs prepared by autopsy revealed the predominant and specific exocrine gland infiltration of ATL cells. Reverse transcription\u2010polymerase chain reaction (RT\u2010PCR) followed by both TCR spectratyping and complementary determining region (CDR)\u20103 sequencing analysis of TCR V<jats:italic>\u03b2<\/jats:italic> of parotid gland\u2010infiltrating T cells revealed a relatively restricted but not single usage of TCR V<jats:italic>\u03b2<\/jats:italic>. Immunohistochemical analyses of parotid gland specimens detected only a small number of TCR V<jats:italic>\u03b1<\/jats:italic><jats:italic>\u03b2<\/jats:italic>\u2010positive cells in parotid gland\u2010infiltrating ATL cells. <jats:italic>Conclusions<\/jats:italic>:\u2002The predominant infiltration of ATL cells in exocrine glands implied that these T cells recognized exocrine gland\u2010specific antigen. However, the absence of both TCR V<jats:italic>\u03b2<\/jats:italic> mRNA transcripts and TCR V<jats:italic>\u03b1<\/jats:italic><jats:italic>\u03b2<\/jats:italic> protein expression in most ATL cells suggested that antigen recognition via TCR may not have played a major role in adhesion and subsequent infiltration into the exocrine glands in this patient. These results provide important background information to further elucidate the pathogenesis of exocrine gland\u2010specific inflammation.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2004.00309.x","type":"journal-article","created":{"date-parts":[[2004,9,30]],"date-time":"2004-09-30T16:19:27Z","timestamp":1096561167000},"page":"332-339","source":"Crossref","is-referenced-by-count":4,"title":["Adult T\u2010cell leukemia predominantly involving exocrine glands"],"prefix":"10.1111","volume":"73","author":[{"given":"Kosuke","family":"Obama","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mineki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Itsuro","family":"Higuchi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsutoshi","family":"Tara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kiyoshige","family":"Niina","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mitsuhiro","family":"Osame","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,9,30]]},"reference":[{"key":"e_1_2_19_2_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(197201)29:1<252::AID-CNCR2820290138>3.0.CO;2-#"},{"key":"e_1_2_19_3_2","first-page":"103","article-title":"Expression of LFA\u20101\/ICAM\u20101 in CNS lymphomas: possible mechanism for lymphoma homing into the brain","volume":"12","author":"Bashir R","year":"1972","journal-title":"J Neurooncol"},{"key":"e_1_2_19_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63802-3"},{"key":"e_1_2_19_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0475"},{"key":"e_1_2_19_6_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.155.5.2487"},{"key":"e_1_2_19_7_2","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1182\/blood.V95.9.2922.009k38_2922_2929","article-title":"Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load","volume":"95","author":"Aarts WM","year":"2000","journal-title":"Blood"},{"key":"e_1_2_19_8_2","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1182\/blood.V50.3.481.481","article-title":"Adult T cell leukemia: Clinical and hematologic features of 16 cases","volume":"50","author":"Uchiyama T","year":"1977","journal-title":"Blood"},{"key":"e_1_2_19_9_2","first-page":"4644","article-title":"Clinical diversity in adult T\u2010cell leukemia\u2010lymphoma","volume":"45","author":"Takatsuki K","year":"1985","journal-title":"Cancer Res"},{"key":"e_1_2_19_10_2","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.75.2.1065-1071.2001"},{"key":"e_1_2_19_11_2","doi-asserted-by":"crossref","first-page":"5109","DOI":"10.4049\/jimmunol.152.10.5109","article-title":"cell repertoire complexity in normal individuals and bone marrow recipients analyzed by CDR3 size spectratyping","volume":"152","author":"Gorski J","year":"1994","journal-title":"J Immunol"},{"key":"e_1_2_19_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1993.tb01991.x"},{"key":"e_1_2_19_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0039.1995.tb03127.x"},{"key":"e_1_2_19_14_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00296518"},{"key":"e_1_2_19_15_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-89-6-888"},{"key":"e_1_2_19_16_2","first-page":"565","article-title":"Non\u2010Hodgkin's lymphoma and Sjogren's syndrome. 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