{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T10:08:10Z","timestamp":1789985290748,"version":"4.0.1"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T00:00:00Z","timestamp":1103587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Reactive hemophagocytic syndrome (RHS) is a disease of overwhelming macrophage activity triggered by infection, malignancy or autoimmune disorders. Currently used laboratory markers for the quantitative assessment of monocyte\/macrophage activation lack lineage\u2010restricted expression patterns and thus specificity. Serum levels of the macrophage specific scavenger receptor CD163 were detemined by enzyme\u2010linked immunosorbent assay (ELISA) and were found to be highly increased in patients with RHS (median 39.0\u2003mg\/L). Significantly lower levels were determined in patients with sepsis (median 9.1\u2003mg\/L), acute mononucleosis (median 8.2\u2003mg\/L), <jats:italic>Leishmania<\/jats:italic> infection (median 6.7\u2003mg\/L) and healthy controls (median 1.8\u2003mg\/L). Follow\u2010up of patients with a relapsing course of the disease revealed close correlations of sCD163 with clinical disease activity, serum ferritin and other markers of macrophage activity. Large sinusoidal accumulations of CD163 expressing macrophages actively engaged in phagocytosis of blood cells were detected in spleen sections of RHS patients. Our data suggests sCD163 to be a macrophage\u2010specific marker in patients with disorders of inappropriate macrophage activation.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2004.00318.x","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T06:34:20Z","timestamp":1103697260000},"page":"6-10","source":"Crossref","is-referenced-by-count":169,"title":["Soluble hemoglobin\u2013haptoglobin scavenger receptor CD163 as a lineage\u2010specific marker in the reactive hemophagocytic syndrome"],"prefix":"10.1111","volume":"74","author":[{"given":"Dominik 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