{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:07:14Z","timestamp":1759342034894},"reference-count":8,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,12,21]],"date-time":"2004-12-21T00:00:00Z","timestamp":1103587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,1]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> A 60\u2010yr\u2010old white woman with CREST syndrome (calcinosis cutis, Raynaud's phenomenon, esophageal involvement, sclerodactyly, telangectasia), idiophatic portal hypertension and esophageal varices presented with a 2\u2010month history of bone pain and severe anemia, requiring erythrocyte transfusion every 5\u20137\u2003d. Initial laboratory findings were hemoglobin (Hb) 4.4\u2003g\/dL, platelets 15\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L, white blood cell count (WBC) 2.7\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L. Bone marrow biopsy showed large areas of BMN, and cultures of bone marrow aspirate were negative. The patient was started on intravenous pulse methylprednisolone (1000\u2003mg\/d for 3\u2003d) followed by oral prednisone (1\u2003mg\/kg\/d), and did not require erythrocyte transfusion thereafter. On the 40th day, our patient had Hb 11.6\u2003g\/dL, platelets 120\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L, WBC 6.2\u2003\u00d7\u200310<jats:sup>9<\/jats:sup>\/L. Here, we describe the first report of BMN in a patient with CREST syndrome, the first description of successful treatment with intravenous pulse corticosteroid and discuss the possible immune mechanisms involved in the present case.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2004.00323.x","type":"journal-article","created":{"date-parts":[[2004,12,22]],"date-time":"2004-12-22T06:34:20Z","timestamp":1103697260000},"page":"75-76","source":"Crossref","is-referenced-by-count":3,"title":["Bone marrow necrosis successfully treated with corticosteroid"],"prefix":"10.1111","volume":"74","author":[{"given":"Alfredo N. 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