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Recombinant human erythropoietin (epoetin) was introduced in 1989 for the treatment of anaemia of chronic kidney disease patients and has maintained an excellent therapeutic and safety record while treating hundreds of thousands of patients. A very rare, but serious adverse event associated with epoetin administration is a condition in which patients develop neutralising anti\u2010erythropoietin antibodies and, consequently, PRCA. This condition is referred to as epoetin\u2010induced PRCA (epo\u2010PRCA). Since it is a rare condition, many haematologists and nephrologists around the world see the condition infrequently and may be uncertain about the diagnosis. For this reason, an <jats:italic>ad hoc<\/jats:italic> international working group of expert haematologists and nephrologists met together to derive new recommendations for the haematological diagnosis of epo\u2010PRCA. These recommendations, which represent the consensus opinions of the working group, address haematological approaches to monitor and investigate suspected epo\u2010PRCA and should help physicians differentiate between PRCA and other bone marrow diseases, as well as, between PRCA and epo\u2010PRCA.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2004.00348.x","type":"journal-article","created":{"date-parts":[[2004,11,2]],"date-time":"2004-11-02T15:24:26Z","timestamp":1099409066000},"page":"389-396","source":"Crossref","is-referenced-by-count":48,"title":["Recommendations on haematological criteria for the diagnosis of epoetin\u2010induced pure red cell aplasia"],"prefix":"10.1111","volume":"73","author":[{"given":"Nicole","family":"Casadevall","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Denis","family":"Cournoyer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith","family":"Marsh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hans","family":"Messner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chris","family":"Pallister","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Parker\u2010Williams","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J\u00e9r\u00f4me","family":"Rossert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,11,2]]},"reference":[{"key":"e_1_2_22_2_2","first-page":"342","volume-title":"Hematology: Basic Principles and Practice","author":"Dessypris EN.","year":"2000"},{"key":"e_1_2_22_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02429.x"},{"key":"e_1_2_22_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfg182"},{"key":"e_1_2_22_5_2","first-page":"266","article-title":"A case of antierythropoietin antibodies following recombinant human erythropoietin treatment","author":"Bergrem H","year":"1993","journal-title":"Erythropoietin: Molecular Physiology and Clinical Application"},{"key":"e_1_2_22_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199608153350717"},{"key":"e_1_2_22_7_2","first-page":"331","article-title":"Antibodies to recombinant human erythropoietin causing pure red cell aplasia","volume":"47","author":"Prabhakar SS","year":"1997","journal-title":"Clin Nephrol"},{"key":"e_1_2_22_8_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199603073341004"},{"key":"e_1_2_22_9_2","unstructured":"Johnson & Johnsonhttp:\/\/www.jnjpharmarnd.com\/company\/news.html. 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