{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T00:38:47Z","timestamp":1768351127650,"version":"3.49.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,3]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Deferiprone is now widely used for iron chelation in patients with thalassaemia. Studies on its efficacy and safety have largely included older children and adults. <jats:italic>Objective:<\/jats:italic>\u2002To assess the safety of deferiprone in children &lt;6\u2003yr of age. <jats:italic>Methods:<\/jats:italic>\u2002The study is based on scrutiny of follow\u2010up data of 44 patients of age &lt;6\u2003yr receiving deferiprone for a variable period of time. Occurrence of various side effects including gastrointestinal, osteoarticular were noticed and complete blood counts were performed every 2\u20134\u2003wk. <jats:italic>Results:<\/jats:italic>\u2002Nausea and vomiting were noticed in 12 (27.2%), joint symptoms were reported by four (9.1%) and neutropenia was observed in only two patients (4.5%). None of the patient had agranulocytosis. Thrombocytopenia was observed in 20 patients (45.45%), which occurred 3\u2003months to 1\u2003yr after deferiprone therapy. Interruption of deferiprone for 2\u20134\u2003wk led to reversal of symptoms in all but two patients. <jats:italic>Conclusion:<\/jats:italic>\u2002Thrombocytopenia is one of the major side effects in young thalassaemics and necessitates frequent close monitoring of blood counts but its resolution after discontinuation and absence of clinical evidence of bleeding does not preclude its use.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2004.00377.x","type":"journal-article","created":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T23:19:09Z","timestamp":1107472749000},"page":"217-220","source":"Crossref","is-referenced-by-count":40,"title":["Safety of oral iron chelator deferiprone in young thalassaemics"],"prefix":"10.1111","volume":"74","author":[{"given":"Rahul","family":"Naithani","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jagdish","family":"Chandra","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharad","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,2,3]]},"reference":[{"key":"e_1_2_11_2_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM196307112690201"},{"key":"e_1_2_11_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(05)80131-3"},{"key":"e_1_2_11_4_2","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1182\/blood.V89.3.739","article-title":"Iron\u2010chelating therapy and the treatment of thalassemia","volume":"89","author":"Oliveri NF","year":"1997","journal-title":"Blood"},{"key":"e_1_2_11_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1995.tb05274.x"},{"key":"e_1_2_11_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03554.x"},{"key":"e_1_2_11_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3280"},{"key":"e_1_2_11_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.1992.tb06445.x"},{"key":"e_1_2_11_9_2","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1182\/blood.V80.3.593.593","article-title":"Efficacy and possible adverse effects of the oral iron chelator 1.2 dimethyl\u20103\u2010hydroxypyrid\u20104\u2010one (1.1) in thalassemia major","volume":"80","author":"Al Refaie EN.","year":"1992","journal-title":"Blood"},{"key":"e_1_2_11_10_2","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1182\/blood.V91.1.295","article-title":"Long term trial of deferiprone in 51 transfusions\u2010dependent iron overloaded patients","volume":"91","author":"Hoffbrand AV.","year":"1998","journal-title":"Blood"},{"key":"e_1_2_11_11_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199808133390701"},{"key":"e_1_2_11_12_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2000.01866.x"},{"key":"e_1_2_11_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)90545-9"},{"key":"e_1_2_11_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(94)92585-2"},{"key":"e_1_2_11_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(89)90642-9"},{"key":"e_1_2_11_16_2","doi-asserted-by":"crossref","first-page":"2727","DOI":"10.1182\/blood.V78.10.2727.2727","article-title":"Comparison of the subacute toxicity and efficacy of 3\u2010hydroxypyrid\u20104\u2010one iron chelators in overloaded and non\u2010overloaded mice","volume":"78","author":"Porter JB","year":"1991","journal-title":"Blood"},{"key":"e_1_2_11_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(93)92443-W"},{"key":"e_1_2_11_18_2","doi-asserted-by":"publisher","DOI":"10.1159\/000204494"},{"key":"e_1_2_11_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1994.tb01323.x"},{"key":"e_1_2_11_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1994.tb01310.x"},{"key":"e_1_2_11_21_2","first-page":"1","article-title":"Oral iron chelation","volume":"33","author":"Hoffbrand AV.","year":"1996","journal-title":"Semin Haematol"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2004.00377.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2004.00377.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,26]],"date-time":"2023-09-26T23:21:37Z","timestamp":1695770497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2004.00377.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,2,3]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2005,3]]}},"alternative-id":["10.1111\/j.1600-0609.2004.00377.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2004.00377.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,2,3]]}}}