{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T04:11:09Z","timestamp":1760242269782},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T00:00:00Z","timestamp":1110931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>  <jats:italic>Objectives<\/jats:italic>:\u2002Classical mantle cell lymphoma (MCL) and its blastoid variant (MCL\u2010BV) are characterized by an extremely poor prognosis. Long\u2010time survivors are rare, only very few patients with an overall survival over 10\u2003years have been reported. We present a case of a 41\u2010year\u2010old male with a 12\u2003yr history of MCL stage I to show, that very late relapses in MCL are possible and may present as a transformation into an aggressive blastoid variant and to illustrate the value of quantitative minimal residual disease (MRD) monitoring for treatment guidance. <jats:italic>Methods<\/jats:italic>:\u2002Diagnostic lymph node and bone marrow samples were investigated by immunohistochemistry. Clonality analysis was performed by immunoglobulin heavy chain gene <jats:italic>(IGVH)<\/jats:italic> and t(11;14) PCR. The MRD assessment was done by real\u2010time quantitative PCR (RQ\u2010PCR) on available follow\u2010up samples. <jats:italic>Results<\/jats:italic>:\u2002By histologic review and sequencing of the clonal <jats:italic>IGVH<\/jats:italic> and t(11;14) PCR products we demonstrated a common clonal origin of the leucemic MCL\u2010BV and the classical MCL diagnosed 12\u2003yr earlier. Quantitative MRD assessment revealed significant MRD levels after intensive conventional chemotherapy including Rituximab. Therefore, treatment was early intensified by myeloablative radio\u2010chemotherapy and allogeneic peripheral stem cell transplantation from an unrelated HLA\u2010identical donor. This did not translate into a sustained remission as reflected by persisting MRD levels after transplantation and the patient died from rapid progressive disease 3.5\u2003months after transplant. <jats:italic>Conclusion<\/jats:italic>:\u2002This report presents a rare case of long\u2010term survivor of MCL with a progression of the original MCL cell clone to MCL\u2010BV and demonstrates the clinical value of quantitative MRD assessment for optimized therapeutic management.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2005.00409.x","type":"journal-article","created":{"date-parts":[[2005,3,16]],"date-time":"2005-03-16T12:18:58Z","timestamp":1110975538000},"page":"353-358","source":"Crossref","is-referenced-by-count":18,"title":["Blastoid variant of mantle cell lymphoma: late progression from classical mantle cell lymphoma and quantitation of minimal residual 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