{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T05:26:32Z","timestamp":1697088392037},"reference-count":5,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T00:00:00Z","timestamp":1115251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We studied a patient with mild <jats:italic>\u03b2<\/jats:italic>\u2010thalassaemia major under treatment with the oral chelator deferiprone (DFP or L1) for about 10\u2003yr (L1 veteran). Due to poor compliance with desferrioxamine, the patient started compassionate use of DFP at an age of 23\u2003yr with a serum ferritin of 5200\u2003<jats:italic>\u03bc<\/jats:italic>g\/L. Monitoring iron overload by SQUID biosusceptometry revealed a dramatic decrease of liver iron concentrations from 4500 to 950\u2003<jats:italic>\u03bc<\/jats:italic>g\/g<jats:sub>liver<\/jats:sub> within 9.5\u2003yr. A good clinical response to chelation treatment with DFP was observed together with an improvement of liver and cardiac function and a reduction in the hepatitis virus load.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2005.00413.x","type":"journal-article","created":{"date-parts":[[2005,5,5]],"date-time":"2005-05-05T19:56:31Z","timestamp":1115322991000},"page":"523-525","source":"Crossref","is-referenced-by-count":3,"title":["Long\u2010term treatment with deferiprone in a L1 veteran"],"prefix":"10.1111","volume":"74","author":[{"given":"Anna","family":"Meo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Ruggeri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Angela La","family":"Rosa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Zangh\u00ec","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Kordes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roland","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,5,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00725.x"},{"key":"e_1_2_6_3_2","first-page":"489","article-title":"Comparative effects of deferiprone and deferoxamine on survival and cardiac disease in patients with thalassemia major: a retrospective analysis","volume":"88","author":"Piga A","year":"2003","journal-title":"Haematologica"},{"issue":"1","key":"e_1_2_6_4_2","first-page":"310a","article-title":"Long\u2010term followup of body iron in patients with thalassemia major during therapy with the orally active iron chelator deferiprone (L1)","volume":"88","author":"Olivieri NF.","year":"1996","journal-title":"Blood"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04297.x"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2001.00367.x"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2005.00413.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2005.00413.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T20:59:43Z","timestamp":1697057983000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2005.00413.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5,5]]},"references-count":5,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2005,6]]}},"alternative-id":["10.1111\/j.1600-0609.2005.00413.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2005.00413.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,5,5]]}}}