{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,18]],"date-time":"2026-06-18T06:27:03Z","timestamp":1781764023337,"version":"3.54.5"},"reference-count":9,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,7,5]],"date-time":"2005-07-05T00:00:00Z","timestamp":1120521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Patients with severe haemophilia A usually present with joint, gastrointestinal and urinary tract haemorrhage. Bleeding elsewhere is often precipitated by pre\u2010existing pathology or trauma. We report a patient with severe haemophilia A, who presented with symptoms of acute intestinal obstruction. He has a factor VIII inhibitor and receives recombinant factor VIIa on demand at home. The CT scan of abdomen showed dilated small intestine with fluid filled loops and a long segment in the jejunum with marked transmural thickening. There was no other pathology in the small intestine. These appearances were consistent with intramural haemorrhage in the small intestine as the cause of acute obstruction. He was managed conservatively with recombinant factor VIIa and this resulted in resolution of his symptoms. This case highlights an unusual presentation of bleeding in a haemophilia patient. Intestinal obstruction due to haemorrhage in the small intestinal wall is extremely rare and only previously reported in a few haemophilia patients. It also highlights the effectiveness of conservative management with recombinant factor VIIa as opposed to immediate exploratory surgery.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2005.00445.x","type":"journal-article","created":{"date-parts":[[2005,7,6]],"date-time":"2005-07-06T06:23:44Z","timestamp":1120631024000},"page":"164-166","source":"Crossref","is-referenced-by-count":9,"title":["Acute intestinal obstruction due to intramural haemorrhage in small intestine in a patient with severe haemophilia A and inhibitor"],"prefix":"10.1111","volume":"75","author":[{"given":"Khaled M. A.","family":"Ramadan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John P.","family":"Lowry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan","family":"Wilkinson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Orla","family":"McNulty","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mary F.","family":"McMullin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francis G. C.","family":"Jones","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,5]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1538-7836.2004.00710.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.2830380212"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1001\/archinte.1984.00350140105015","article-title":"Spontaneous intra\u2010abdominal hemorrhage in hemophilia","volume":"144","author":"Jones JJ","year":"1984","journal-title":"Arch Intern Med"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.04807.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-03-0941"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2000.02463.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1055\/s-0038-1650216","article-title":"Safety profile of porcine factor VIII and its use as hospital and home\u2010therapy for patients with haemophilia\u2010A and inhibitors: the results of an international survey","volume":"75","author":"Hay CR","year":"1996","journal-title":"J Thromb Haemost"},{"key":"e_1_2_5_9_2","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1055\/s-0037-1615876","article-title":"Treatment of patients with factor VIII and factor IX inhibitors with special focus on the use of recombinant factor VIIa","volume":"82","author":"Hedner U","year":"1999","journal-title":"J Thromb Haemost"},{"key":"e_1_2_5_10_2","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1055\/s-0037-1615388","article-title":"Home treatment of mild to moderate bleeding episodes using recombinant factor VIIa (Novoseven) in haemophiliacs with inhibitors","volume":"80","author":"Key NS","year":"1998","journal-title":"J Thromb Haemost"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2005.00445.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2005.00445.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T00:24:03Z","timestamp":1695774243000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2005.00445.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7,5]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2005,8]]}},"alternative-id":["10.1111\/j.1600-0609.2005.00445.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2005.00445.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,7,5]]}}}