{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T01:03:04Z","timestamp":1792371784706,"version":"4.4.0"},"reference-count":28,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T00:00:00Z","timestamp":1123200000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,9]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> In Gaucher disease, a deficiency of glucocerebrosidase results in the accumulation of glucocerebroside within the lysosomes of the monocyte\u2013macrophage system. Prior to the availability of enzyme replacement therapy (ERT), splenectomy was often indicated for hypersplenism. Haemorheological abnormalities could be expected in view of the anaemia and abnormal lipid metabolism in these patients and the role of the spleen in controlling erythrocyte quality. <jats:italic>Objectives:<\/jats:italic> To investigate the effect of Gaucher disease on blood and plasma viscosity, erythrocyte aggregation and erythrocyte deformability, and to determine whether observed rheological differences could be attributed to splenectomy. <jats:italic>Methods:<\/jats:italic> Haematological and haemorheological measurements were made on blood collected from 26 spleen\u2010intact patients with Gaucher disease, 16 splenectomised patients with Gaucher disease, 6 otherwise healthy asplenic non\u2010Gaucher disease subjects and 15 healthy controls. <jats:italic>Results:<\/jats:italic> No haemorheological differences could be demonstrated between spleen\u2010intact patients with Gaucher disease and the control group. Compared to controls, both asplenic Gaucher disease and asplenic non\u2010Gaucher disease study groups had a reduced MCHC (<jats:italic>P<\/jats:italic>\u2003=\u20030.003 and 0.005, respectively) and increased whole blood viscosity at 45% haematocrit (Hct), relative viscosity and red cell aggregation index \u2013 all measured at low shear (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05 for all). Additionally, asplenic patients with Gaucher disease alone showed an increased MCV (<jats:italic>P<\/jats:italic>\u2003=\u20030.006), an increased whole blood viscosity at 45% Hct measured at high shear (<jats:italic>P<\/jats:italic>\u2003=\u20030.019), and a reduced relative filtration rate (<jats:italic>P<\/jats:italic>\u2003=\u20030.0001), compared to controls. <jats:italic>Conclusion:<\/jats:italic> These observations demonstrate a direct and measurable haemorheological abnormality in Gaucher disease only revealed when there is no functioning spleen to control erythrocyte quality.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2005.00496.x","type":"journal-article","created":{"date-parts":[[2005,8,5]],"date-time":"2005-08-05T16:26:59Z","timestamp":1123259219000},"page":"252-258","source":"Crossref","is-referenced-by-count":21,"title":["Haemorheology in Gaucher disease"],"prefix":"10.1111","volume":"75","author":[{"given":"Bridget 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