{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T16:44:33Z","timestamp":1788799473361,"version":"build-2803163510"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,7,5]],"date-time":"2005-07-05T00:00:00Z","timestamp":1120521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,8]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>  <jats:italic>Objectives<\/jats:italic>:\u2002Combined high\u2010dose Interferon\u2010<jats:italic>\u03b1<\/jats:italic> and psoralen plus ultraviolet A irradiation (PUVA) have been reported to be effective in the treatment of early mycosis fungoides (MF); however, our study is the first controlled prospective study in the literature exploring the activity and tolerability of the combination with low dosages and evaluating further clinical outcome of early\u2010MF patients. <jats:italic>Methods<\/jats:italic>:\u2002We carried out a multicentric prospective Phase II clinical study on 89 patients with early\u2010stage IA to IIA MF treated for 14\u2003months with low\u2010dose IFN\u2010<jats:italic>\u03b1<\/jats:italic>2b (6\u201318\u2003MU\/wk) and PUVA. Treatment success was analysed in terms of freedom from treatment failure. <jats:italic>Results and conclusions<\/jats:italic>:\u2002Complete remission (CR) was achieved in 84% and an overall response rate in 98% of cases: six\u2010month CR was associated with a non\u2010confluent skin infiltrate at histology (<jats:italic>P<\/jats:italic>\u2003=\u20030.044) and 14\u2010month CR with high epidermal CD1a+ dendritic\u2010cell density (<jats:italic>P<\/jats:italic>\u2003=\u20030.030). The combination protocol was successfully tolerated and the most common reason of \u2018failure\u2019 was related to relapse and not to toxicity. Sustained remissions were achieved in 20% of patients. High CD8+ lymphoid T\u2010cell density was associated with a lower relapse rate (<jats:italic>P<\/jats:italic>\u2003=\u20030.002). We think that our combination therapy can be considered an alternative approach compared with other modalities. Good immunological host surveillance in the skin lesions seems to be an optimal basis for the therapeutic success.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2005.00497.x","type":"journal-article","created":{"date-parts":[[2005,7,6]],"date-time":"2005-07-06T06:23:44Z","timestamp":1120631024000},"page":"136-145","source":"Crossref","is-referenced-by-count":58,"title":["Long\u2010term experience with low\u2010dose interferon\u2010<i>\u03b1<\/i> and PUVA in the management of early mycosis fungoides"],"prefix":"10.1111","volume":"75","author":[{"given":"Serena","family":"Rupoli","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaia","family":"Goteri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Pulini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Filosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Tassetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Offidani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Filosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgio","family":"Mozzicafreddo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Giacchetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuliano","family":"Brandozzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivana","family":"Cataldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Barulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renzo","family":"Ranaldi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna Rita","family":"Scortechini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Capretti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guidalberto","family":"Fabris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pietro","family":"Leoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"(for the Marche Regional Multicentric Study Group of Cutaneous Lymphomas)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,7,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.139.7.857"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(95)90241-4"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.7.2385.bloodjournal8872385"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.123482"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-59410-6_36"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2002.120911"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1067\/mjd.2003.80"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.4.1636"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1993.tb01595.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/1523-1747.ep12875523"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.1.257"},{"key":"e_1_2_6_13_2","first-page":"3578","article-title":"Prospective randomized multicenter clinical trial on the use of interferon \u03b1\u20102a plus acitretin versus interferon \u03b1\u20102a plus PUVA in patients with cutaneous T cell lymphoma stages I and II","volume":"92","author":"Stadler R","year":"1998","journal-title":"Blood"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10706"},{"key":"e_1_2_6_15_2","first-page":"809","article-title":"Low dose interferon\u2010alpha2b combined with PUVA is an effective treatment of early stage mycosis fungoides: results of a multicenter study. 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