{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T01:14:18Z","timestamp":1697418858446},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2005,9,28]],"date-time":"2005-09-28T00:00:00Z","timestamp":1127865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Fanconi anaemia (FA) is a rare genetic disease whose patients have a high predisposition to haematological abnormalities and cancer. Fas expression levels in peripheral blood lymphocytes samples of 73 FA patients were measured to verify if alterations in Fas expression could lead to predisposition\/resistance to spontaneous or PHA induced apoptosis, as well as, to reflect some haematological features of this disease. The anti\u2010 and pro\u2010apoptotic proteins Bcl\u20102 and Bax were also evaluated. FA patients samples could be divided into three different groups based on Fas expression: 20 samples had low, 32 normal and 21 increased Fas levels when compared to 41 control samples. No correlation was found between Fas and Bcl\u20102 expression but a good association was obtained with Bax, in the subgroup with increased Fas expression. The best correlation was seen between Bax expression and apoptosis. Out of the 15 samples with high Bax expression, 11 underwent apoptosis whereas only one out of seven samples with low levels of Bax displayed increased induced apoptosis. Most patients with normal haematological features expressed Fas within normal levels. It is difficult to establish, however, if Fas\u2010expression is involved in the cause or is a consequence of the effects observed.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2005.00534.x","type":"journal-article","created":{"date-parts":[[2005,9,28]],"date-time":"2005-09-28T12:56:53Z","timestamp":1127912213000},"page":"384-390","source":"Crossref","is-referenced-by-count":5,"title":["Apoptosis and expression of anti\u2010 and pro\u2010apoptotic proteins in peripheral blood mononuclear cells of Fanconi anaemia patients: a study of 73 cases"],"prefix":"10.1111","volume":"75","author":[{"given":"Gra\u00e7a A.","family":"Baruque","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco A.","family":"Bitencourt","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricardo","family":"Pasquini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morgana T. 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