{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,9,6]],"date-time":"2024-09-06T09:42:20Z","timestamp":1725615740756},"reference-count":29,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,10]],"date-time":"2005-11-10T00:00:00Z","timestamp":1131580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>  <jats:italic>Objectives<\/jats:italic>:\u2002Proliferation indices are important prognostic factors for the clinical outcome of patients with mantle cell lymphoma (MCL). We investigated whether the expression of repp86 (restrictedly expressed proliferation\u2010associated protein 86\u2003kDa), a new proliferation specific marker expressed in the cell cycle phases G<jats:sub>2<\/jats:sub>, S and M, but not in G<jats:sub>1<\/jats:sub>, correlates with the clinical course in patients with MCL. <jats:italic>Patients and Methods<\/jats:italic>:\u2002Biopsy specimens from 94 untreated patients enrolled in two multicenter trials were investigated immunohistochemically with monoclonal antibodies against CD20, CD5, CD3, CD23, cyclin D1, and repp86 (Ki\u2010S2). <jats:italic>Results<\/jats:italic>:\u2002Patients with 0\u20131% repp86 expression had a median overall survival time of 71.0\u2003months, compared with 38.2\u2003months for patients with 1\u20135% positive cells and 25.4\u2003months for patients with 5\u201310% positive tumor cells. Patients with repp86 expression of more than 10% showed the shortest survival (median: 15.0\u2003months). Kaplan\u2013Meier analysis revealed a significant difference in the overall survival time between patients with very high (&gt;10%) and very low (0\u20131%) repp86 expression (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001) in the tumor cells. The multivariate analysis revealed repp86 expression to be superior to other clinical characteristics as a prognostic factor (<jats:italic>P<\/jats:italic>\u2003=\u20030.0016). <jats:italic>Conclusion<\/jats:italic>:\u2002Based on these findings, repp86 expression is a new important prognostic factor in MCL.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2005.00540.x","type":"journal-article","created":{"date-parts":[[2005,11,10]],"date-time":"2005-11-10T10:52:49Z","timestamp":1131619969000},"page":"498-504","source":"Crossref","is-referenced-by-count":15,"title":["Repp86: a new prognostic marker in mantle cell lymphoma"],"prefix":"10.1111","volume":"75","author":[{"given":"Carsten","family":"Schrader","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dirk","family":"Janssen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Meusers","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00fcnter","family":"Brittinger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens U.","family":"Siebmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Parwaresch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Markus","family":"Tiemann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,10]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"29","article-title":"Cytological and functional criteria for the classification of malignant lymphomata","volume":"31","author":"Lennert K","year":"1975","journal-title":"Br J Cancer"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.6610211"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(94)90543-6"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900020406"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.6.2067"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.01677.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00028-X"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.133.4.1710"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.2910310104"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1159\/000218858"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V90.1.226"},{"key":"e_1_2_6_13_2","first-page":"271","article-title":"Repp86: a human protein associated in the progression of mitosis","volume":"1","author":"Heidebrecht HJ","year":"2003","journal-title":"Mol Cancer Res"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.149.7.1405"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/91.3.271"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2003.05.076"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(99)90249-6"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900020306"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.2900070505"},{"key":"e_1_2_6_20_2","volume-title":"World Health Organization Classification of Tumours. 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