{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T01:10:10Z","timestamp":1697332210089},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2005,11,10]],"date-time":"2005-11-10T00:00:00Z","timestamp":1131580800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2005,12]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Chronic graft\u2010vs.\u2010host disease (cGVHD) occurs in 20\u201350% of patients who survive for at least 100\u2003d after allogeneic stem cell transplantation (SCT). cGVHD includes scleroderma\u2010like skin changes, chronic cholangitis, obstructive lung disease and general wasting syndrome. Polymyositis or myopathy are rare manifestations of cGVHD with approximately 40 reported cases. Polymyositis accompanied by hemosiderin deposits in cGVHD has been reported only once, and there are no reports on lipofuscin deposits in skeletal muscle cells in cGVHD. We report here on a 56\u2010yr\u2010old male who underwent allogeneic SCT in 1999 for osteomyelofibrosis and progressive hematopoietic insufficiency. In February 2004, the patient was hospitalized for progressive muscular weakness with loss of the ability to walk. Laboratory tests demonstrated normal values for serum creatine kinase, aldolase and lactic dehydrogenase; the ferritin level was highly elevated. The femoral muscle biopsy showed mostly perifascicular atrophy as well as numerous subsarcolemmal hemosiderin and lipofuscin deposits. Intravenous administration of the chelating agent deferoxamine was ineffective. Three weeks later the patient died of aspiration pneumonia. Interestingly, autopsy disclosed moderate hemosiderin deposits in the liver, the organ usually involved in hemosiderosis.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2005.00548.x","type":"journal-article","created":{"date-parts":[[2005,11,10]],"date-time":"2005-11-10T10:52:49Z","timestamp":1131619969000},"page":"522-526","source":"Crossref","is-referenced-by-count":3,"title":["Hemosiderin deposits in chronic graft\u2010vs.\u2010host disease related myopathy"],"prefix":"10.1111","volume":"75","author":[{"given":"Martin","family":"Schmidt\u2010Hieber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Fuat","family":"Okuducu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gisela","family":"Stoltenburg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno\u2010Marcel","family":"Mackert","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nadia","family":"Benzian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eckhard","family":"Thiel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Igor Wolfgang","family":"Blau","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2005,11,10]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8588(18)30482-9"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1097\/00062752-199801000-00004"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701575"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00002281-199711000-00006"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1053\/bbmt.2002.v8.abbmt080674"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-199609000-00004"},{"key":"e_1_2_4_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keg025"},{"key":"e_1_2_4_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703665"},{"key":"e_1_2_4_10_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.39.482"},{"key":"e_1_2_4_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00115-002-1465-2"},{"key":"e_1_2_4_12_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702688"},{"key":"e_1_2_4_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/10245330290022115"},{"key":"e_1_2_4_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/thorax.56.1.82"},{"key":"e_1_2_4_15_2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1007\/BF02987746","article-title":"Case report: acute polymyositis in a patient with chronic graft vs. host disease","volume":"9","author":"Ascensao JL","year":"1992","journal-title":"Med Oncol Tumor Pharmacother"},{"key":"e_1_2_4_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002960000091"},{"key":"e_1_2_4_17_2","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.39.444"},{"key":"e_1_2_4_18_2","doi-asserted-by":"publisher","DOI":"10.1016\/0190-9622(91)70240-3"},{"key":"e_1_2_4_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703711"},{"key":"e_1_2_4_20_2","first-page":"612","article-title":"Skeletal muscle pathology of chronic graft versus host disease accompanied with myositis, affecting predominantly respiratory and distal muscles, and hemosiderosis","volume":"41","author":"Oya Y","year":"2001","journal-title":"Rinsho Shinkeigaku"},{"key":"e_1_2_4_21_2","doi-asserted-by":"publisher","DOI":"10.1080\/1042819031000079096"},{"key":"e_1_2_4_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8619(18)30877-6"},{"key":"e_1_2_4_23_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199111213252107"},{"key":"e_1_2_4_24_2","first-page":"445","article-title":"Histopathologic aspects of polymyositis and dermatomyositis. 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