{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:43:14Z","timestamp":1789900994513,"version":"4.0.1"},"reference-count":15,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T00:00:00Z","timestamp":1132272000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2006,1]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Light chain deposition disease (LCDD) is a multisystemic disorder seen in the setting of plasma cell dyscrasias. The histological characteristic of this disorder is the deposition of a homogeneous, granular, slightly eosinophilic and non\u2010Congophilic material that shows immunostaining for monoclonal light chains (<jats:italic>\u03ba<\/jats:italic> or <jats:italic>\u03b3<\/jats:italic>), while in primary amyloidosis (AL) the proteinaceous substance is fibrillar and Congo red positive. In contrast with AL, the light chain in LCDD is usually of the <jats:italic>\u03ba<\/jats:italic>\u2010type. Renal involvement, resulting in nephrotic syndrome, is usually the prominent feature of LCDD. Patients with this disease may also have heart, liver or other organ involvement, mimicking the picture of primary systemic amyloidosis. However, liver failure has rarely been described in patients with LCDD. A patient with myeloma\u2010associated LCDD who developed rapidly progressive liver <jats:italic>\u03ba<\/jats:italic> light chain deposition with fatal outcome after undergoing the first cycle of vincristine\/doxorubicin\/dexamethasone chemotherapy is reported.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2005.00561.x","type":"journal-article","created":{"date-parts":[[2005,11,18]],"date-time":"2005-11-18T10:36:45Z","timestamp":1132310205000},"page":"83-85","source":"Crossref","is-referenced-by-count":24,"title":["Development of rapidly progressive liver light chain deposition under VAD chemotherapy in multiple myeloma"],"prefix":"10.1111","volume":"76","author":[{"given":"C\u00e9sar","family":"Samanez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abel","family":"Domingo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma Teresa","family":"Cibeira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Miquel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manel","family":"Soler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joan","family":"Blad\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2005,11,18]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-76-3-112-6-455"},{"key":"e_1_2_5_3_2","first-page":"150","article-title":"Light chain nephropathy: histological and clinical aspects in\u00a015 cases","volume":"3","author":"Confalonieri R","year":"1988","journal-title":"Nephrol Dial Transplant"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198805000-00009"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-110-4-275"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199805000-00013"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.ajkd.2003.08.040"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1523-1755.2004.00427.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0168-8278(91)90913-V"},{"key":"e_1_2_5_10_2","first-page":"683","article-title":"Liver involvement in non\u2010amyloid light chain deposits disease","volume":"50","author":"Droz D","year":"1984","journal-title":"Lab Invest"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0046-8177(88)80078-9"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1136\/pgmj.64.756.804"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/snep.2002.33673"},{"key":"e_1_2_5_14_2","first-page":"167","article-title":"D\u00e9pots h\u00e9patiques et renaux de chaines l\u00e9g\u00e8res kappa r\u00e9velateurs d'une dysglobulinemie","volume":"1","author":"Mignon F","year":"1980","journal-title":"Nephrologie"},{"key":"e_1_2_5_15_2","doi-asserted-by":"crossref","first-page":"3655","DOI":"10.1182\/blood.V86.10.3655.bloodjournal86103655","article-title":"Role of light chain variable region in myeloma with light chain deposition disease: evidence from an experimental model","volume":"86","author":"Kramlichi AA","year":"1995","journal-title":"Blood"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1014773512707"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2005.00561.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2005.00561.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,27]],"date-time":"2023-09-27T04:35:23Z","timestamp":1695789323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2005.00561.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,11,18]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2006,1]]}},"alternative-id":["10.1111\/j.1600-0609.2005.00561.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2005.00561.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2005,11,18]]}}}