{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T23:03:09Z","timestamp":1782255789681,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,3,27]],"date-time":"2006-03-27T00:00:00Z","timestamp":1143417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> We report a prospective study of 174 unselected adult <jats:italic>de novo<\/jats:italic> acute myeloid leukemia (AML) cases diagnosed using the WHO classification. Of those, 57 (33%) were AML with recurrent cytogenetic abnormalities, 41 were (24%) AML with multilineage dysplasia, 74 (42%) were AML not otherwise categorized, and two were acute leukemias of ambiguous lineage. Clonal cytogenetic abnormalities were detected in 64% of the WHO AML cases with t(15;17) (15%), t(8;21) (12%), +8 (11%), \u22127\/del7q (8%) and del9q (5%) being the most common ones. The <jats:italic>FLT3<\/jats:italic>\/ITD mutations (<jats:italic>FMS<\/jats:italic>\u2010like tyrosine kinase 3\/internal tandem duplication) were observed in 12% of the WHO AML cases, which is much lower than ones in the literature, while the 6% incidence of the <jats:italic>FLT3<\/jats:italic>\u2010activating loop mutations (either <jats:italic>FLT3<\/jats:italic>\/D835 or <jats:italic>FLT3<\/jats:italic>\/I836) was comparable with others. Both mutations were associated with leukocytosis. Our study also suggests that the <jats:italic>FLT3<\/jats:italic> mutations are biomarkers independent of cytogenetic characteristics.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2006.00660.x","type":"journal-article","created":{"date-parts":[[2006,3,27]],"date-time":"2006-03-27T11:56:18Z","timestamp":1143460578000},"page":"35-45","source":"Crossref","is-referenced-by-count":30,"title":["Prospective study of 174 <i>de novo<\/i> acute myelogenous leukemias according to the WHO classification: subtypes, cytogenetic features and <i>FLT3<\/i> 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