{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,21]],"date-time":"2026-06-21T17:26:44Z","timestamp":1782062804885,"version":"3.54.5"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,5,17]],"date-time":"2006-05-17T00:00:00Z","timestamp":1147824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2006,8]]},"abstract":"<jats:title>Abstract:<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Limited data are available on the cardiac effects of high\u2010dose cyclophosphamide (CY) in patients with non\u2010Hodgkin's lymphoma (NHL). We prospectively assessed the cardiac effects of high\u2010dose CY in 30 adult NHL patients receiving CY 6\u2003g\/m<jats:sup>2<\/jats:sup> as part of BEAC high\u2010dose therapy (HDT).<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Radionuclide ventriculography (RVG) and plasma natriuretic peptide (NT\u2010proANP, NT\u2010proBNP) measurements were performed simultaneously prior to BEAC at baseline (d\u2003\u2212\u20037), 12\u2003days (d\u2003+\u200312) and 3\u2003months (m\u2003+\u20033) after stem cell infusion (D0). In addition to these time points, natriuretic peptides were measured 2\u2003days before (d\u2003\u2212\u20032) and 1\u2003week (d\u2003+\u20037) after stem cell infusion.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Left ventricular ejection fraction (LVEF) decreased from d\u2003\u2212\u20037 (53%\u2003\u00b1\u20032%) to d\u2003+\u200312 (49%\u2003\u00b1\u20032%, <jats:italic>P<\/jats:italic>\u2003=\u20030.009). However, no significant change in cardiac diastolic function was observed. The LVEF returned towards baseline by m\u2003+\u20033. Plasma NT\u2010proANP and NT\u2010proBNP increased significantly from baseline (445\u2003\u00b1\u200365\u2003pmol\/L and 129\u2003\u00b1\u200333\u2003pmol\/L) to d\u2003\u2212\u20032 (1127\u2003\u00b1\u2003142\u2003pmol\/L, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001 and 624\u2003\u00b1\u2003148\u2003pmol\/L, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001, respectively). Thereafter, they started to decrease, but on d\u2003+\u20037 NT\u2010proANP (404\u2003\u00b1\u2003157\u2003pmol\/L, <jats:italic>P<\/jats:italic>\u2003=\u20030.048) and NT\u2010proBNP (648\u2003\u00b1\u2003125\u2003pmol\/L, <jats:italic>P<\/jats:italic>\u2003=\u20030.015) were still significantly higher than at baseline. On d\u2003+\u200312 and m\u2003+\u20033 they no longer differed from baseline.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> Our findings suggest that high\u2010dose CY results in acute, subclinical systolic dysfunction in NHL patients previously treated with anthracyclines. Natriuretic peptides seem to be more sensitive than LVEF to reflect this transient cardiac effect. Serial measurements of natriuretic peptides might be a useful tool to assess cardiac effects of high\u2010dose CY.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2006.00687.x","type":"journal-article","created":{"date-parts":[[2006,5,17]],"date-time":"2006-05-17T16:19:51Z","timestamp":1147882791000},"page":"120-127","source":"Crossref","is-referenced-by-count":30,"title":["Cardiac effects within 3\u2003months of BEAC high\u2010dose therapy in non\u2010Hodgkin's lymphoma patients undergoing autologous stem cell transplantation"],"prefix":"10.1111","volume":"77","author":[{"given":"T.","family":"Kuittinen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Jantunen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vanninen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Mussalo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Vuolteenaho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Ala\u2010Kopsala","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Nousiainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Hartikainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,5,17]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704653"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704763"},{"key":"e_1_2_6_4_2","first-page":"91","article-title":"Cardiac involvement in bone marrow transplantation: electrocardiographic changes, arrhythmias, heart failure and autopsy findings","volume":"5","author":"Kupari M","year":"1990","journal-title":"Bone Marrow Transpl"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19860515)57:10<2061::AID-CNCR2820571031>3.0.CO;2-H"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1001\/archinte.1981.00340060066015"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(76)90151-3"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703133"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6601001"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.0000130926.51766.CC"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1994.12.5.998"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1991.9.7.1215"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehi559"},{"key":"e_1_2_6_14_2","first-page":"949","article-title":"Subclinical disturbances in cardiac function at rest and in gas exchange during exercise are common findings after autologous bone marrow transplantation","volume":"14","author":"Carlson K","year":"1994","journal-title":"Bone Marrow Transpl"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.01661.x"},{"key":"e_1_2_6_16_2","first-page":"549","article-title":"High\u2010dose chemotherapy with BEAC regimen and autologous bone marrow transplantation for intermediate grade and immunoblastic lymphoma: durable complete remission, but a high rate of regimen\u2010related toxicity","volume":"15","author":"Van Besien K","year":"1995","journal-title":"Bone Marrow Transpl"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705175"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1373\/49.2.248"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1703132"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0006"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002770100331"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702507"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2005.050153"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.12.3835"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291402"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(79)90148-6"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(86)90028-7"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1373\/clinchem.2004.032490"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2005.07.029"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.104.472050"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20010102"},{"key":"e_1_2_6_32_2","first-page":"1113","article-title":"Demonstration of late cardiotoxicity following bone marrow transplantation by assessment of exercise diastolic filling characteristics","volume":"17","author":"Lele SS","year":"1996","journal-title":"Bone Marrow Transpl"},{"key":"e_1_2_6_33_2","first-page":"1000","article-title":"Subclionical cardiotoxicity by doxorubicin: a pulsed doppler echogardiographic study","volume":"12","author":"Cittadini A","year":"1991","journal-title":"Eur Heart J"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejheart.2004.03.009"},{"key":"e_1_2_6_35_2","first-page":"173","article-title":"Radionuclide ejection fraction in the evaluation of patients being considered for bone marrow transplantation: risk for cardiac toxicity","volume":"5","author":"Bearman SI","year":"1990","journal-title":"Bone Marrow Transpl"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1701734"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702234"},{"key":"e_1_2_6_38_2","first-page":"859","article-title":"Angiotensin converting enzyme inhibitors in bone marrow transplant recipients with depressed left ventricular function","volume":"15","author":"Kakavas PW","year":"1995","journal-title":"Bone Marrow Transpl"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdj003"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(00)02051-1"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2006.00687.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2006.00687.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:11:36Z","timestamp":1696990296000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2006.00687.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,5,17]]},"references-count":39,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["10.1111\/j.1600-0609.2006.00687.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2006.00687.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,5,17]]}}}