{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T13:45:00Z","timestamp":1764510300925},"reference-count":48,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2006,7,19]],"date-time":"2006-07-19T00:00:00Z","timestamp":1153267200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold> Among 460 consecutive patients with essential thrombocythemia (ET) seen at our institution, 19 cases (4%) of abdominal vein thrombosis (AVT) were documented either at (<jats:italic>n<\/jats:italic>\u2003=\u20039) or after (<jats:italic>n<\/jats:italic>\u2003=\u200310) diagnosis. Women (<jats:italic>P<\/jats:italic>\u2003=\u20030.03) and the young (<jats:italic>P<\/jats:italic>\u2003=\u20030.002) were preferentially affected. Accordingly, clinical comparisons were performed among three groups of female patients: those with AVT (group A; <jats:italic>n<\/jats:italic>\u2003=\u200317), a control group without AVT but closely matched to group A in terms of age and year of diagnosis (group B; <jats:italic>n<\/jats:italic>\u2003=\u200334), and all female patients without AVT (group C; <jats:italic>n<\/jats:italic>\u2003=\u2003288). As expected from the consequences of AVT\u2010associated portal hypertension and anticoagulant therapy, patients in group A experienced significantly higher rates of hemorrhage, palpable splenomegaly, and anemia. Unexpectedly, however, compared with group B, group A displayed both a higher conversion rate into myelofibrosis\/acute leukemia (<jats:italic>P<\/jats:italic>\u2003=\u20030.0008) and a shorter median survival (116 vs. 156\u2003months; <jats:italic>P<\/jats:italic>\u2003=\u20030.0012). Multivariable analysis including all female patients with ET identified AVT, along with advanced age, leukocytosis, and tobacco use, as an independent risk factor for inferior survival. Groups A, B, and C did not differ in either JAK2<jats:sup>V617F<\/jats:sup> mutational frequency or incidence of non\u2010abdominal thrombosis. We conclude that AVT in ET is a marker of aggressive disease biology.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2006.00715.x","type":"journal-article","created":{"date-parts":[[2006,7,20]],"date-time":"2006-07-20T15:13:05Z","timestamp":1153408385000},"page":"327-333","source":"Crossref","is-referenced-by-count":35,"title":["Abdominal vein thrombosis in essential thrombocythemia: prevalence, clinical correlates, and prognostic implications"],"prefix":"10.1111","volume":"77","author":[{"given":"Naseema","family":"Gangat","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandra P.","family":"Wolanskyj","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayalew","family":"Tefferi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05277.x"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0741-5214(95)70013-7"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01725198"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.qjmed.a030135"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510310307"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90567-7"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(86)90855-3"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1440-1746.2000.02157.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(94)80140-1"},{"key":"e_1_2_5_11_2","first-page":"2364","article-title":"Factor V Leiden mutation, prothrombin gene mutation, and deficiencies in coagulation inhibitors associated with Budd\u2013Chiari syndrome and portal vein thrombosis: results of a case\u2013control study","volume":"96","author":"Janssen HL","year":"2000","journal-title":"Blood"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1159\/000040942"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0025-6196(12)65200-8"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.5.720"},{"key":"e_1_2_5_15_2","first-page":"981","article-title":"In vitro colony culture and chromosomal studies in hepatic and portal vein thrombosis \u2013 possible evidence of an occult myeloproliferative state","volume":"76","author":"Pagliuca A","year":"1990","journal-title":"Q J Med"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-3-329"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996117"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1995.tb00703.x"},{"key":"e_1_2_5_19_2","doi-asserted-by":"crossref","first-page":"728a","DOI":"10.1182\/blood.V106.11.2588.2588","article-title":"Prevalence of the activating JAK2 tyrosine kinase mutation V617F in the Budd\u2013Chiari Syndrome","volume":"106","author":"Patel RK","year":"2005","journal-title":"Blood"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2257.2002.00444.x"},{"key":"e_1_2_5_21_2","first-page":"17","volume-title":"World Health Organization Classification of Tumors: Tumours of the Haematopoietic and Lymphoid Tissues","author":"Vardiman JW"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-03-1183"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.1978.01370180055006"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1007\/s002689900521"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.7.2226"},{"key":"e_1_2_5_26_2","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1055\/s-0038-1648435","article-title":"Hematological causes of venous thrombosis in young people: high incidence of myeloproliferative disorder as underlying disease in patients with splanchnic venous thrombosis","volume":"67","author":"Teofili L","year":"1992","journal-title":"Thromb Haemost"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-996117"},{"key":"e_1_2_5_28_2","first-page":"149","article-title":"Prevalence of specific thrombotic accidents in patients with thrombocytosis","volume":"25","author":"Randi ML","year":"1993","journal-title":"Haematologia (Budap)"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.10254"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19910515)67:10<2658::AID-CNCR2820671042>3.0.CO;2-C"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.4065\/81.2.159"},{"key":"e_1_2_5_32_2","first-page":"215","article-title":"Practice guidelines for the therapy of essential thrombocythemia. A statement from the Italian Society of Hematology, the Italian Society of Experimental Hematology and the Italian Group for Bone Marrow Transplantation","volume":"89","author":"Barbui T","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_5_33_2","first-page":"1180","article-title":"Splenectomy after portal thrombosis in patients with polycythemia vera and essential thrombocythemia","volume":"87","author":"Randi ML","year":"2002","journal-title":"Haematologica"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-09-3426"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(00)80259-7"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2005.01.015"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0049-3848(98)00005-X"},{"key":"e_1_2_5_38_2","first-page":"169","article-title":"Increased platelet and leukocyte activation as contributing mechanisms for thrombosis in essential thrombocythemia and correlation with the JAK2 mutational status","volume":"91","author":"Arellano\u2010Rodrigo E","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1002\/lt.500050211"},{"key":"e_1_2_5_40_2","doi-asserted-by":"crossref","first-page":"730a","DOI":"10.1182\/blood.V106.11.2594.2594","article-title":"Estrogen\u2010based hormone therapy and thrombosis risk in women with essential thrombocythemia","volume":"106","author":"Gangat N","year":"2005","journal-title":"Blood"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3188"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.2005.00522.x"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.21209"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199504273321704"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043800"},{"key":"e_1_2_5_46_2","first-page":"2098","article-title":"Thrombolytic treatment of portal thrombosis","volume":"50","author":"Malkowski P","year":"2003","journal-title":"Hepatogastroenterology"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00270-004-0241-z"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1746.2005.03878.x"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200210270-00006"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2006.00715.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2006.00715.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T02:22:53Z","timestamp":1696990973000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2006.00715.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,19]]},"references-count":48,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2006,10]]}},"alternative-id":["10.1111\/j.1600-0609.2006.00715.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2006.00715.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,19]]}}}