{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,1,16]],"date-time":"2024-01-16T01:22:35Z","timestamp":1705368155174},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,7,27]],"date-time":"2006-07-27T00:00:00Z","timestamp":1153958400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:p><jats:bold>Abstract:\u2002<\/jats:bold>  <jats:italic>Objectives:<\/jats:italic>\u2002This study was designed to evaluate the efficacy and toxicity of the modified B\u2010Non\u2010Hodgkin's Lymphoma (NHL)\u2010Berlin\u2010Frankfurt\u2010M\u00fcnster (BFM)\u201090\u2010based protocol in Chinese children and adolescents with Burkitt's lymphoma and large cell lymphoma.<\/jats:p><jats:p> <jats:italic>Methods:<\/jats:italic>\u2002From September 1997 to August 2005, 55 untreated patients (age less than 20\u2003yr) from a single institution were enrolled. The patients were stratified by risk factors (stage, LDH level and chemotherapy response). All patients were treated with a modified B\u2010NHL\u2010BFM 90 protocol.<\/jats:p><jats:p> <jats:italic>Results:<\/jats:italic>\u2002The median age of the patients was 8\u2003yr (range 1.5\u201320\u2003yr). Of these patients, 22 (40%) had Burkitt's lymphoma (BKL), 22 (40%) had diffuse large B\u2010cell lymphoma (DLBL) and 11 (20%) had anaplastic large T\u2010cell lymphoma (ALCL). Complete remission (CR) occurred in 45 patients (83%), partial remission (PR) in eight patients (14.5%), and progressive disease (PD) in one patient (1.8%). At a median follow up of 24\u2003months, the event free survival (EFS) for all patients was 85%\u2003\u00b1\u20035% with 100% for group R1, 84%\u2003\u00b1\u20037% for group R2 and 72%\u2003\u00b1\u200313% for group R3, and most notably, 80%\u2003\u00b1\u20036% for stage III\/IV at diagnosis. There was no statistically significant difference (<jats:italic>P<\/jats:italic>\u2003=\u20030.96) in EFS among BKL and DLBL and ALCL. The major toxicity complications were myelosuppression and mucositis, but these conditions were tolerated and manageable.<\/jats:p><jats:p> <jats:italic>Conclusions:<\/jats:italic>\u2002This modified NHL\u2010BFM\u201090 protocol is very effective for Chinese children and adolescents with BKL and large cell lymphomas, and represented an increase in the cure rates in childhood NHL in China.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2006.00735.x","type":"journal-article","created":{"date-parts":[[2006,7,27]],"date-time":"2006-07-27T11:00:40Z","timestamp":1153998040000},"page":"365-371","source":"Crossref","is-referenced-by-count":12,"title":["Improved treatment outcome in Chinese children and adolescents with Burkitt's lymphoma and large cell lymphoma by using the modified B\u2010non\u2010Hodgkin's lymphoma\u2010Berlin\u2010Frankfurt\u2010M\u00fcnster\u201090 protocol"],"prefix":"10.1111","volume":"77","author":[{"given":"Xiao\u2010Fei","family":"Sun","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zi\u2010Jun","family":"Zhen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Gen","family":"Lui","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You\u2010Jian","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi\u2010Hui","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia\u2010yu","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhong\u2010Zhen","family":"Guan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,7,27]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1995.13.2.359"},{"key":"e_1_2_5_3_2","first-page":"3294","article-title":"Improved treatment results in childhood B\u2010cell neoplasms with tailored intensification of therapy: a report of the Berlin\u2010Frankfurt\u2010Munster Group trial NHL\u2010BFM90","volume":"94","author":"Reiter A","year":"1999","journal-title":"Blood"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.11.3370"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2003.04134.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.08.088"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.3109\/10428199909145953"},{"key":"e_1_2_5_8_2","first-page":"416","article-title":"Intensive ALL\u2010type therapy without local radiotherapy provides a 90% event\u2010free survival for children with T\u2010cell lymphoblastic lymphoma: a BFM group report","volume":"95","author":"Reiter A","year":"2000","journal-title":"Blood"},{"key":"e_1_2_5_9_2","first-page":"933","article-title":"Comparing CHOP, CHOP+HD\u2010MTX with BFM\u201090 regimen in the survival rate for childhood and adolescence with B\u2010cell non\u2010hodgkin's lymphoma","volume":"23","author":"Sun X\u2010F","year":"2004","journal-title":"Chin J Cancer"},{"key":"e_1_2_5_10_2","first-page":"332","article-title":"Classification, staging and end results of treatment in childhood non\u2010Hodgkin's lymphoma: dissimilarities from lymphomas in adults","volume":"7","author":"Murphy SB","year":"1980","journal-title":"Semin Oncol"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200407000-00014"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-911X(199705)28:5<333::AID-MPO2>3.0.CO;2-I"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1080\/088800199277254"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.12.3699"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03147.x"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6602040"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.2.414"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00043426-200403000-00004"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-03-0973"},{"key":"e_1_2_5_20_2","doi-asserted-by":"crossref","first-page":"697","DOI":"10.1200\/JCO.2001.19.3.697","article-title":"Recombinant urate oxidase for the prophylaxis or treatment of hyperuricemia in patients with Leukemia or Lymphoma","volume":"19","author":"Ching\u2010Hon P","year":"2001","journal-title":"J Clin Oncol"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V97.10.2998"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdf134"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2006.00735.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2006.00735.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T03:48:42Z","timestamp":1697428122000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2006.00735.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,7,27]]},"references-count":21,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2006,11]]}},"alternative-id":["10.1111\/j.1600-0609.2006.00735.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2006.00735.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,7,27]]}}}