{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:19:48Z","timestamp":1787678388573,"version":"build-2784847793"},"reference-count":9,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:italic>Objectives:<\/jats:italic>\u2002The main adverse effect of deferiprone is the development of neutropenia, which occurs via an unknown mechanism. We aimed to gain insight into the pathogenesis of deferiprone\u2010induced neutropenia by assessing the peripheral blood haematopoietic progenitor cells. <jats:italic>Methods:<\/jats:italic>\u2002Sixteen patients with beta thalassaemia were studied; nine (Group A) were receiving desferrioxamine and seven (Group B) deferiprone. Ten healthy individuals comprised the control group (Group C). <jats:italic>Results:<\/jats:italic>\u2002Granulocyte\u2010erythrocyte\u2010monocyte\u2010megakaryocyte colony forming units were significantly more in Groups A and B compared with Group C. Granulocyte\u2010macrophage colony forming units (CFU\u2010GM) were significantly more in Group B compared with Group C. Macrophage colony forming units were significantly less in Group B compared with Group C. Granulocyte colony forming units (CFU\u2010G) were significantly more in Group A compared with Group C. We found a trend in the difference in the number of CFU\u2010G between patients\u2019 groups (<jats:italic>P<\/jats:italic>\u2003=\u20030.123). Adding serum from patients receiving deferiprone to cultures of controls resulted in a maturation arrest of the granulocytic lineage. <jats:italic>Conclusion:<\/jats:italic>\u2002Our findings point to a maturation arrest at the level of CFU\u2010GM as a potential mechanism of deferiprone\u2010induced neutropenia.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2006.00773.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T08:29:05Z","timestamp":1161160145000},"page":"48-51","source":"Crossref","is-referenced-by-count":18,"title":["Peripheral blood haematopoietic progenitor cells in patients with beta thalassaemia major receiving desferrioxamine or deferiprone as chelation therapy"],"prefix":"10.1111","volume":"78","author":[{"given":"Efthimia","family":"Vlachaki","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elissavet","family":"Ioannidou\u2010Papagiannaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantinos","family":"Tziomalos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Styliani","family":"Haralambidou\u2010Vranitsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vassilios","family":"Perifanis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Klonizakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miranda","family":"Athanassiou\u2010Metaxa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,11,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1006\/bcmd.2002.0510"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03554.x"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-07-2948"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0950-3536(98)80040-1"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/stem.5530100605"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199905)61:1<40::AID-AJH8>3.0.CO;2-0"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1081\/HEM-100103064"},{"key":"e_1_2_5_9_2","first-page":"33","volume-title":"Potent Iron Chelators Affect Multiple Genes Involved in the p53 Tumor Suppressor Pathway and Cell Cycle Control: A Gene Array Study. 13th International Conference on Oral Chelation in the Treatment of Thalassaemia and Other Diseases","author":"Le NTV","year":"2003"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0609.1994.tb01310.x"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2006.00773.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2006.00773.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:16:37Z","timestamp":1696983397000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2006.00773.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,22]]},"references-count":9,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1600-0609.2006.00773.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2006.00773.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,22]]}}}