{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T13:35:00Z","timestamp":1700487300506},"reference-count":52,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Several studies have reported data on factors influencing mobilization of peripheral blood stem cells (PBSC) in non\u2010myeloid malignancies. On the contrary, data from patients with acute myeloid leukemia (AML) are very limited, in particular, as the impact of an antecedent diagnosis of refractory anemia with excess blasts (RAEB) on mobilization of PBSCs as well as hematopoietic recovery after autologous stem cell transplantation (ASCT) is concerned. We retrospectively analyzed a cohort of 150 consecutive AML patients in first complete remission in order to make a comparison between patients with <jats:italic>de novo<\/jats:italic> AML and secondary AML (s\u2010AML) in terms of CD34 positive (CD34+) cells mobilization and number of leukapheresis needed to collect at least one single stem cell graft. Data concerning hematopoietic recovery after ASCT were also compared. The successful mobilization rate (&gt;2\u2003\u00d7\u200310<jats:sup>6<\/jats:sup> CD34+ cells\/kg) was comparable between <jats:italic>de novo<\/jats:italic> AML patients (87%) and those with s\u2010AML (76%), <jats:italic>P<\/jats:italic>:0.21. No statistically significant difference was found in terms of either median number of CD34+ cells collected (<jats:italic>P<\/jats:italic>:0.44) or CD34+ cells peak in peripheral blood (<jats:italic>P<\/jats:italic>:0.28). Both groups of patients needed a median of two apheresis (<jats:italic>P<\/jats:italic>:0.45) and no difference was found on the median number of CD34+ cells collected per single apheresis (<jats:italic>P<\/jats:italic>:0.59). Finally, neutrophil and platelet recovery after ASCT were comparable between the two groups. An antecedent diagnosis of RAEB has no impact on mobilization and collection of PBSCs in AML as well as on hematopoietic recovery after ASCT.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2006.00777.x","type":"journal-article","created":{"date-parts":[[2006,10,18]],"date-time":"2006-10-18T08:29:05Z","timestamp":1161160145000},"page":"41-47","source":"Crossref","is-referenced-by-count":2,"title":["An antecedent diagnosis of refractory anemia with excess blasts has no influence on mobilization of peripheral blood stem cells and hematopoietic recovery after autologous stem cell transplantation in acute myeloid leukemia"],"prefix":"10.1111","volume":"78","author":[{"given":"Assunta","family":"Viola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio","family":"Falco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rossella","family":"D'Elia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria R.","family":"D'Amico","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Vicari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco P.","family":"Tambaro","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasqualino","family":"Correale","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniela","family":"Laudati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Salvatore","family":"Palmieri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felicetto","family":"Ferrara","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,11,22]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/beha.2000.0116"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi051"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdl083"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1686"},{"key":"e_1_2_5_6_2","first-page":"2722","article-title":"A placebo\u2010controlled study of recombinant human granulocyte\u2010macrophage colony\u2010stimulating factor administered during and after induction treatment for de novo acute myelogenous leukemia in elderly patients. Groupe Ouest Est Leucemies Aigues Myeloblastiques (GOELAM)","volume":"91","author":"Witz F","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V98.5.1302"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.04.5013"},{"key":"e_1_2_5_9_2","first-page":"1339","article-title":"Allogeneic stem cell transplantation for patients with acute myeloid leukemia or myelodysplastic syndrome who have chromosome 5 and\/or 7 abnormalities","volume":"90","author":"Van Der Straaten HM","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.11.007"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2005.02.0057"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2005.1.151"},{"key":"e_1_2_5_13_2","first-page":"750","article-title":"The role of stem cell source in autologous hematopoietic stem cell transplantation for patients with myelodysplastic syndromes","volume":"91","author":"De Witte T","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_5_14_2","first-page":"373","article-title":"Long\u2010term follow\u2010up of autologous stem cell transplantation after intensive chemotherapy in patients with myelodysplastic syndrome or secondary acute myeloid leukemia","volume":"91","author":"Ducastelle S","year":"2006","journal-title":"Haematologica"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705226"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1705265"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1997.15.2.535"},{"key":"e_1_2_5_18_2","first-page":"311","article-title":"Factors affecting mobilization of peripheral blood progenitor cells in patients with lymphoma","volume":"4","author":"Moskowitz CH","year":"1998","journal-title":"Clin Cancer Res"},{"key":"e_1_2_5_19_2","first-page":"342","article-title":"Peripheral blood progenitor cell collections in cancer patients: analysis of factors affecting the yields","volume":"84","author":"Sautois B","year":"1999","journal-title":"Haematologica"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-0502(03)00097-1"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1182\/asheducation-2003.1.419"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1532\/IJH97.A30411"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0145-2126(02)00068-1"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1998.00614.x"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-103-4-620"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.6.1295"},{"key":"e_1_2_5_27_2","first-page":"1990","article-title":"Interstitial 9q deletion is associated with CD7+ acute leukemia of myeloid and T lymphoid lineage","volume":"10","author":"Ferrara F","year":"1996","journal-title":"Leukemia"},{"key":"e_1_2_5_28_2","first-page":"2322","article-title":"The importance of diagnostic cytogenetics on outcome in AML: analysis of 1612 patients entered into the MRC AML 10 trial. The Medical Research Council Adult and Children's Leukaemia Working Parties","volume":"92","author":"Grimwade D","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_29_2","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1182\/blood.V89.6.2079","article-title":"International Scoring System for evaluating prognosis in myelodysplastic syndromes","volume":"89","author":"Greenberg P","year":"1998","journal-title":"Blood"},{"key":"e_1_2_5_30_2","first-page":"776","article-title":"Fludarabine and cytarabine as continuous sequential infusion for elderly patients with acute myeloid leukaemia","volume":"90","author":"Ferrara F","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1704611"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05303.x"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1080\/01621459.1958.10501452"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(04)01512-8"},{"key":"e_1_2_5_35_2","first-page":"235","article-title":"Stem cell transplantation in acute myelogenous leukemia in first remission: what are the options","volume":"3","author":"Mathews V","year":"2004","journal-title":"Curr Hematol Rep"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2004.05282.x"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199501263320403"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199812033392301"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(97)09214-3"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djh003"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.02806.x"},{"key":"e_1_2_5_42_2","first-page":"791","article-title":"Feasibility and results of autologous stem cell transplantation in de novo acute myeloid leukemia in patients over 60\u2003years old. Results of the CETLAM AML\u201099 protocol","volume":"89","author":"Oriol A","year":"2004","journal-title":"Haematologica"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2005.12.027"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21006"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2005-09-3724"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.transci.2004.09.008"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2005.06.001"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.7292351.x"},{"key":"e_1_2_5_49_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V86.10.3660.bloodjournal86103660"},{"key":"e_1_2_5_50_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1999.01379.x"},{"key":"e_1_2_5_51_2","doi-asserted-by":"publisher","DOI":"10.1080\/1042819021000035608"},{"key":"e_1_2_5_52_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1449"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.01651.x"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2006.00777.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2006.00777.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T00:17:02Z","timestamp":1696983422000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2006.00777.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,11,22]]},"references-count":52,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1600-0609.2006.00777.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2006.00777.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,11,22]]}}}