{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T18:39:30Z","timestamp":1791398370428,"version":"4.3.3"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T00:00:00Z","timestamp":1165968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:italic>Objectives:<\/jats:italic>\u2002The aim of this study was to explore the profile and function of CD4<jats:sup>+<\/jats:sup>CD25<jats:sup>+<\/jats:sup> regulatory T cells (Treg cells) in idiopathic thrombocytopenic purpura (ITP) patients. <jats:italic>Methods:<\/jats:italic>\u2002Treg cell numbers were analyzed by flow cytometric analysis in peripheral blood mononuclear cells collected from healthy donors or patients with ITP. Quantification of cell proliferation was assayed by an enzyme\u2010linked immunosorbent assay kit, based on the measurement of BrdU incorporation during DNA synthesis. <jats:italic>Results:<\/jats:italic>\u2002The percentage of Treg cells was significantly decreased in ITP patients in active and non\u2010remission state(5.79\u2003\u00b1\u20031.22%) when compared with the patients in remission(11.63\u2003\u00b1\u20034.56%) and to healthy subjects(12.68\u2003\u00b1\u20033.59%). The suppressive activity of Treg cells in ITP patients was also found to be impaired. <jats:italic>Conclusion:<\/jats:italic>\u2002These results suggest that decreased number and function of Treg cells might be one of mechanisms that cause immune regulation dysfunction in ITP.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2006.00780.x","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T05:22:41Z","timestamp":1166073761000},"page":"139-143","source":"Crossref","is-referenced-by-count":222,"title":["Abnormality of CD4<sup>+<\/sup>CD25<sup>+<\/sup> regulatory T cells in idiopathic thrombocytopenic purpura"],"prefix":"10.1111","volume":"78","author":[{"given":"Bin","family":"Liu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man\u2010Chiu","family":"Poon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibo","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongsheng","family":"Gu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maoqiang","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hairong","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renchi","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhong 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