{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T21:58:12Z","timestamp":1780091892376,"version":"3.54.0"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T00:00:00Z","timestamp":1170892800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objectives:\u2002<\/jats:bold> Angioimmunoblastic T\u2010cell lymphoma (AIL) is a rare lymphoma with a poor prognosis and no standard treatment. Here, we report our experiences with 19 patients treated with high\u2010dose chemotherapy and autologous stem cell transplantation (HDC\/ASCT) within the GELTAMO co\u2010operative group between 1992 and 2004.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> The median age at transplantation was 46\u2003yr. Fifteen patients underwent the procedure as front\u2010line therapy and four patients as salvage therapy. Most patients received peripheral stem cells (90%) coupled with BEAM or BEAC as conditioning regimen (79%).<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> A 79% of patients achieved complete response, 5% partial response and 16% failed the procedure. After a median follow\u2010up of 25\u2003months, eight patients died (seven of progressive disease and secondary neoplasia), while actuarial overall survival and progression\u2010free survival at 3\u2003yr was 60% and 55%. Prognostic factors associated with a poor outcome included bone marrow involvement, transplantation in refractory disease state, attributing more than one factor of the age\u2010adjusted\u2010International Prognostic Index, Pretransplant peripheral T\u2010cell lymphoma (PTCL) Score or Prognostic Index for PTCL.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> More than half of the patients with AIL that display unfavourable prognostic factors at diagnosis or relapse would be expected to be alive and disease\u2010free after 3\u2003yr when treated with HDC\/ASCT. Patients who are transplanted in a refractory disease state do not benefit from this procedure.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00815.x","type":"journal-article","created":{"date-parts":[[2007,2,8]],"date-time":"2007-02-08T09:17:53Z","timestamp":1170926273000},"page":"290-296","source":"Crossref","is-referenced-by-count":52,"title":["Prolonged survival of patients with angioimmunoblastic T\u2010cell lymphoma after high\u2010dose chemotherapy and autologous stem cell transplantation. The GELTAMO 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