{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T08:26:14Z","timestamp":1771489574848,"version":"3.50.1"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T00:00:00Z","timestamp":1170633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Telomere length was recently reported to correlate with cellular origin of B\u2010cell malignancies in relation to the germinal center (GC). In this report, we measured telomere length by quantitative\u2010PCR in 223 B\u2010cell lymphomas\/leukemias and correlated results with immunoglobulin (Ig) mutation status and immunostainings for GC\/non\u2010GC subtypes of diffuse large B\u2010cell lymphoma (DLBCL). Shortest telomeres were found in Ig\u2010unmutated chronic lymphocytic leukemia (CLL) [median telomere to single copy gene value (T\/S) 0.33], differing significantly to Ig\u2010mutated CLL (0.63). Contrary to this, mantle cell lymphomas (MCLs) exhibited similar telomere lengths regardless of Ig mutation status (0.47). Telomere length differed significantly between GC\u2010like (0.73) and non\u2010GC\u2010like DLBCLs (0.43), and follicular lymphomas (FLs) had shorter telomeres (0.53) than GC\u2010DLBCL. Hairy cell leukemias, which display <jats:italic>Ig<\/jats:italic> gene intraclonal heterogeneity, had longer telomeres (0.62) than FLs and non\u2010GC\u2010DLBCL, but shorter than GC\u2010DLBCL. We conclude that although DLBCL and CLL subsets can be clearly distinguished, telomere length reflects many parameters and may not simply correlate with GC\u2010related origin.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00817.x","type":"journal-article","created":{"date-parts":[[2007,2,5]],"date-time":"2007-02-05T18:31:49Z","timestamp":1170700309000},"page":"283-289","source":"Crossref","is-referenced-by-count":13,"title":["Telomere length and correlation with histopathogenesis in B\u2010cell leukemias\/lymphomas"],"prefix":"10.1111","volume":"78","author":[{"given":"Sarah H.","family":"Walsh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pawel","family":"Grabowski","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mattias","family":"Berglund","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulf","family":"Thunberg","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mia","family":"Thors\u00e9lius","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerard","family":"Tobin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"\u00c5leskog","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Karlsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christer","family":"Sundstr\u00f6m","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Laurell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gunilla","family":"Enblad","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Rosenquist","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G\u00f6ran","family":"Roos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,5]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.1.222.222"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2001.00588.x"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.20.10827"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412007"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4412"},{"key":"e_1_2_6_7_2","first-page":"4918","article-title":"Telomere length and telomerase activity predict survival in patients with B cell chronic lymphocytic leukemia","volume":"58","author":"Bechter OE","year":"1998","journal-title":"Cancer Res"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-04-1345"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-11-4394"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjc.6600763"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-11-3479"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0609.2002.01662.x"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1383"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2004.05.016"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa012914"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1038\/35000501"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.180316097"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800396"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-05-1545"},{"key":"e_1_2_6_20_2","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1182\/blood.V78.6.1561.1561","article-title":"Ig VH gene expression among human follicular lymphomas","volume":"78","author":"Bahler DW","year":"1991","journal-title":"Blood"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.15.6770"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2004.12.008"},{"key":"e_1_2_6_23_2","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1182\/blood.V100.4.1505.h81602001505_1505_1507","article-title":"Typical Waldenstrom macroglobulinemia is derived from a B\u2010cell arrested after cessation of somatic mutation but prior to isotype switch events","volume":"100","author":"Sahota SS","year":"2002","journal-title":"Blood"},{"key":"e_1_2_6_24_2","volume-title":"World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.6.2262"},{"key":"e_1_2_6_26_2","first-page":"465","article-title":"Patients with chronic lymphocytic leukemia with mutated VH genes presenting with Binet stage B or C form a subgroup with a poor outcome","volume":"90","author":"Tobin G","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_6_27_2","first-page":"230","article-title":"Detection of clonal B cell populations in paraffin\u2010embedded tissues by polymerase chain reaction","volume":"143","author":"Kuppers R","year":"1993","journal-title":"Am J Pathol"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/30.10.e47"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1084\/jem.182.2.559"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.1.226"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.3.1166"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0346"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0047-6374(03)00018-6"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2002.03910.x"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2007.00817.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2007.00817.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T22:11:56Z","timestamp":1696975916000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2007.00817.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,5]]},"references-count":33,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,4]]}},"alternative-id":["10.1111\/j.1600-0609.2007.00817.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2007.00817.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,5]]}}}