{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T08:10:57Z","timestamp":1765267857946},"reference-count":10,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T00:00:00Z","timestamp":1171584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Transfusional iron overload in patients with chronic anemias can result in multiple organ failure. Experience in the management of iron overload in patients with myelodysplastic syndromes is limited, as many do not receive chelation therapy due to short\u2010life expectancy and the difficulties associated with the administration of the current reference standard chelator, deferoxamine. There have, however, been some reports of reduced transfusion requirement associated with chelation therapy in patients with myelodysplastic syndromes and myelofibrosis. Here, we discuss a patient with primary myelofibrosis and related transfusion\u2010dependent anemia who received chelation therapy with the once\u2010daily oral iron chelator, deferasirox. In addition to the reduced iron levels, the patient demonstrated an unexpected reduction in blood transfusion requirement, ultimately resulting in long\u2010lasting transfusion\u2010free survival.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00840.x","type":"journal-article","created":{"date-parts":[[2007,3,28]],"date-time":"2007-03-28T14:35:35Z","timestamp":1175092535000},"page":"540-542","source":"Crossref","is-referenced-by-count":49,"title":["Correction of anemia in a transfusion\u2010dependent patient with primary myelofibrosis receiving iron chelation therapy with deferasirox (Exjade<b><sup>\u00ae<\/sup><\/b>, ICL670)"],"prefix":"10.1111","volume":"78","author":[{"given":"Anna Angela","family":"Di Tucci","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Murru","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Alberti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bertrand","family":"Rabault","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"Deplano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Emanuele","family":"Angelucci","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,2,16]]},"reference":[{"key":"e_1_2_3_2_2","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Haematopoietic and Lymphoid Tissues","author":"Jaffe ES","year":"2001"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V88.3.1013.1013"},{"key":"e_1_2_3_4_2","first-page":"1128","article-title":"European consensus of grading bone marrow fibrosis and assessment of cellularity","volume":"90","author":"Thiele J","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009746"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.1996.d01-1795.x"},{"key":"e_1_2_3_7_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8652(199603)51:3<243::AID-AJH12>3.0.CO;2-H"},{"key":"e_1_2_3_8_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2001-12-0349"},{"key":"e_1_2_3_9_2","doi-asserted-by":"crossref","first-page":"11576","DOI":"10.1016\/S0021-9258(18)90901-4","article-title":"Regulation of transferrin receptors in human hematopoietic cell lines","volume":"259","author":"Louache F","year":"1984","journal-title":"J Biol Chem"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000204488"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01140577"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2007.00840.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2007.00840.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T23:54:17Z","timestamp":1696982057000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2007.00840.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,2,16]]},"references-count":10,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2007,6]]}},"alternative-id":["10.1111\/j.1600-0609.2007.00840.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2007.00840.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,2,16]]}}}