{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T14:41:19Z","timestamp":1780411279353,"version":"3.54.1"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,3,14]],"date-time":"2007-03-14T00:00:00Z","timestamp":1173830400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Objective:\u2002<\/jats:bold>Retrospective data shows that peripheral T\u2010cell lymphoma (PTCL) patients sensitive to conventional chemotherapy for aggressive lymphomas may respond better if this treatment is consolidated with frontline autologous stem cell transplantation (ASCT). Here, we present data from a prospective phase II trial of high\u2010dose chemotherapy and ASCT as a frontline consolidation therapy for aggressive nodal PTCL.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold>This study involved 26 gallium\u2010scan\u2010positive patients with high\u2010risk nodal PTCL [excluding anaplastic lymphoma kinase (ALK) positive]. Patients received three courses of MegaCHOP before they were evaluated, and those that were gallium\u2010scan\u2010negative at this stage then received another course of MegaCHOP and ASCT. Patients who remained gallium\u2010scan\u2010positive received two courses of an IFE regimen (ifosfamide 10\u2003g\/m<jats:sup>2<\/jats:sup>, etoposide 150\u2003mg\/m<jats:sup>2<\/jats:sup>\/12\u2003h on days 1\u20103) and if they at least achieved PR, they then received the transplant.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold>Complete response (CR) was achieved by 12 patients (46%) after three courses of MegaCHOP and 12 patients received IFE as a salvage therapy. After the ASCT (<jats:italic>n<\/jats:italic>\u2003=\u200319), 89% of patients achieved CR. In contrast, six patients (23%) did not receive the transplant because of the progression of the disease (<jats:italic>n<\/jats:italic>\u2003=\u20035) or lethal toxicity (<jats:italic>n<\/jats:italic>\u2003=\u20031). One patient in first\u2010line CR refused ASCT. After a median follow\u2010up of 35\u2003months, the overall survival (OS) and progression\u2010free survival (PFS) at 3\u2003yr was 73% and 53%, respectively. Moreover, the OS, PFS and disease\u2010free survival (DFS) were 84%, 56% and 63%, respectively 2\u2003yr after transplant in patients who received ASCT consolidation (<jats:italic>n<\/jats:italic>\u2003=\u200319).<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold>Early salvage therapy for patients with high\u2010risk aggressive nodal PTCL that do not achieve CR after three courses of chemotherapy and ASCT frontline consolidation for chemosensitive patients may improve treatment outcome.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00856.x","type":"journal-article","created":{"date-parts":[[2007,6,26]],"date-time":"2007-06-26T10:56:20Z","timestamp":1182855380000},"page":"32-38","source":"Crossref","is-referenced-by-count":134,"title":["Frontline autologous stem cell transplantation in high\u2010risk peripheral T\u2010cell lymphoma: a prospective study from The Gel\u2010Tamo Study Group"],"prefix":"10.1111","volume":"79","author":[{"given":"Jos\u00e9","family":"Rodr\u00edguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eulogio","family":"Conde","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reyes","family":"Arranz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c1ngel","family":"Le\u00f3n","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juli\u00e1n","family":"Mar\u00edn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Bendandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmen","family":"Albo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Dolores","family":"Caballero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"On behalf of the \u2018Grupo Espa\u00f1ol de Linfomas\/Trasplante Aut\u00f3logo de M\u00e9dula \u00d3sea\u2019 (GEL\u2010TAMO)","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,3,14]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1209178"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403960"},{"key":"e_1_2_5_4_2","doi-asserted-by":"crossref","first-page":"811","DOI":"10.1182\/blood.V106.11.811.811","article-title":"International peripheral T\u2010cell lymphoma (PTCL) clinical and pathologic review project: poor outcome by prognostic indices and lack of efficacy with anthracyclines","volume":"106","author":"Vose J","year":"2005","journal-title":"Blood"},{"key":"e_1_2_5_5_2","doi-asserted-by":"crossref","first-page":"4514","DOI":"10.1182\/blood.V89.12.4514","article-title":"Evaluation of the revised European\u2010American lymphoma classification confirms the clinical relevance of immunophenotype in 560 cases of aggressive non\u2010Hodgkin\u2019s lymphoma","volume":"89","author":"Melnyk A","year":"1997","journal-title":"Blood"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1989.7.12.1783"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.annonc.a057673"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2001.19.17.3766"},{"key":"e_1_2_5_9_2","first-page":"646a","article-title":"Similar outcomes for chemosensitive (CS) relapsed or primary refractory peripheral T\u2010cell lymphoma (PTCL) and diffuse large B\u2010cell lymphoma (DLBCL) treated with autologous transplantation (ASCT)","volume":"100","author":"Kewalramani T","year":"2002","journal-title":"Blood"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg008"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702867"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdg459"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.4.1244"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21979"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.1977.1"},{"key":"e_1_2_5_16_2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.2517-6161.1972.tb00899.x","article-title":"Regression models and life\u2010tables","volume":"34","author":"Cox DR","year":"1972","journal-title":"J R Stat Soc"},{"key":"e_1_2_5_17_2","doi-asserted-by":"crossref","DOI":"10.1182\/blood.V106.11.2074.2074","article-title":"Autologous Stem Cell Transplantation as First\u2010Line Therapy in Peripheral T\u2010Cell Lymphomas. 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