{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,16]],"date-time":"2023-10-16T05:41:13Z","timestamp":1697434873961},"reference-count":48,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,4,10]],"date-time":"2007-04-10T00:00:00Z","timestamp":1176163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>An unusual case having IgM monoclonal gammopathy with clinical and pathologic features of multiple myeloma (MM) in association with neutrophilia and nephrotic syndrome is reported. The patient showed lytic bone lesions, decreased IgG and IgA levels, Bence\u2010Jones proteinuria, nephrotic proteinuria with edema, and histological plasma cell infiltration typical of MM. Moreover, mature neutrophilic leukocytosis, hepatomegaly, high leukocyte alkaline phosphatase score (LAP), absence of Philadelphia (Ph) chromosome and bcr gene rearrangement were also evidenced, all these features representing findings typical of the recently described plasma cell dyscrasia\u2010associated neutrophilia. After the diagnosis, the patient was treated with melphalan and prednisone, with an excellent response to the treatment. Different from the 30 cases so far reported, this is the first case of plasma\u2010cell dyscrasia with associated neutrophilia due to IgM\u2010producing monoclonal gammopathy. At the same time, this is the first reported case of nephrotic syndrome secondary to IgM myeloma.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00869.x","type":"journal-article","created":{"date-parts":[[2007,6,26]],"date-time":"2007-06-26T10:56:20Z","timestamp":1182855380000},"page":"76-80","source":"Crossref","is-referenced-by-count":4,"title":["Nephrotic syndrome in a patient with IgM myeloma with associated neutrophilia"],"prefix":"10.1111","volume":"79","author":[{"given":"Paola","family":"Gnerre","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luciano","family":"Ottonello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabrizio","family":"Montecucco","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Boero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Franco","family":"Dallegri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,4,10]]},"reference":[{"key":"e_1_2_4_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.beha.2005.01.008"},{"key":"e_1_2_4_3_2","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdi717"},{"key":"e_1_2_4_4_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2004-01-0037"},{"key":"e_1_2_4_5_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-10-3017"},{"key":"e_1_2_4_6_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF03165139"},{"key":"e_1_2_4_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1054-3589(04)51013-X"},{"key":"e_1_2_4_8_2","first-page":"497","article-title":"Association of polycythemia vera and multiple myeloma. 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