{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T10:12:36Z","timestamp":1788516756132,"version":"build-2803163510"},"reference-count":26,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,5,21]],"date-time":"2007-05-21T00:00:00Z","timestamp":1179705600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Lymphomas are currently categorized according to their origin from a B or T lymphocyte. Immature and less commonly mature (peripheral) lymphomas may harbor rearrangements of both the B\u2010 and T\u2010cell antigen receptor genes (dual genotype or bigenotype). Rarely, cells in lymphoma with a single genotype simultaneously express both B\u2010 and T\u2010cell markers (biphenotypic lymphomas). We discuss the diagnostic and clinical implications in the case of a 42\u2010yr\u2010old female with a peripheral CD30<jats:sup>+<\/jats:sup> lymphoma that displayed both characteristic B\u2010 and T\u2010cell surface antigens and clonal rearrangement of B\u2010 and T\u2010cell antigen receptor gene loci. Simultaneous nuclear expression of the transcription factor gene <jats:italic>PAX5<\/jats:italic> suggested that this major driver of B\u2010cell differentiation did not preclude expression of CD3\u03b5, generally assumed to be a T\u2010cell associated antigen.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00882.x","type":"journal-article","created":{"date-parts":[[2007,6,30]],"date-time":"2007-06-30T14:37:11Z","timestamp":1183214231000},"page":"159-165","source":"Crossref","is-referenced-by-count":15,"title":["Biphenotypic bigenotypic lymphoma with simultaneous expression of PAX5\/BSAP and B\u2010 and T\u2010cell markers"],"prefix":"10.1111","volume":"79","author":[{"given":"Markus","family":"Hansson","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mats","family":"Jerkeman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Dictor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6,19]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880133"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3880265"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1192"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2404479"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1002\/hon.660"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00153-4"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/44076"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.leu.2403202"},{"key":"e_1_2_5_10_2","first-page":"1524","article-title":"Resolving T\u2010cell receptor clonality in two and genotype in four multiplex polymerase chain reactions","volume":"90","author":"Dictor M","year":"2005","journal-title":"Haematologica"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63055-6"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65443-0"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199910000-00008"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V96.6.2254"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.20163"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-005-0034-z"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200206000-00005"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/path.1126"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/102.4.483"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800742"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800355"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni1339"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200210000-00011"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1002\/gcc.20214"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2006-03-009670"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1038\/35085588"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2141.2006.06425.x"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2007.00882.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2007.00882.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:06:59Z","timestamp":1697342819000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2007.00882.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,6,19]]},"references-count":26,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,8]]}},"alternative-id":["10.1111\/j.1600-0609.2007.00882.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2007.00882.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,6,19]]}}}