{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T09:25:04Z","timestamp":1790673904922,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,6,1]],"date-time":"2007-06-01T00:00:00Z","timestamp":1180656000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background:\u2002<\/jats:bold>  <jats:sup>18<\/jats:sup>Fluoro\u20102\u2010deoxyglucose (<jats:sup>18<\/jats:sup>FDG) positron emission tomography (PET) is widely used for initial staging and follow\u2010up in patients with malignant lymphoma. While earlier studies suggested a limited role for PET in extranodal marginal zone mucosa\u2010associated lymphoid tissue (MALT) lymphoma patients due to their non\u2010FDG avidity, more recent reports have suggested that the issue is controversial. In the present study, we evaluated the diagnostic accuracy of PET integrated with CT (PETCT) in patients with MALT lymphoma and assessed its reliability in clinical staging and monitoring response.<\/jats:p><jats:p><jats:bold>Methods:\u2002<\/jats:bold> Thirty\u2010three patients with biopsy proven MALT lymphoma in 37 sites, who underwent PET\/CT at diagnosis, were enrolled. Medical records, PET\/CT findings and data obtained by other diagnostic procedures were reviewed.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> Common sites of MALT lymphoma were the stomach (18), lung (5), orbit (4), and parotid gland (3). PET\/CT detected active disease in 18 of 33 patients (54.5%) at diagnosis. Sensitivity in gastric MALT (38.9%) was lower when compared with non\u2010gastric MALT (75%). PET\/CT detected active disease in 100% patients with advanced disease (stage III\u2013IV) but only in 42.3% with early stage disease (I\u2013II). The incidence of gastric FDG uptake was higher in patients showing gastric ulcer on gastroscopy than in subjects with minimal or no macroscopic findings. Of the 33 patients in the study cohort, 12 had a follow\u2010up PET\/CT which detected relapse in three patients.<\/jats:p><jats:p><jats:bold>Conclusions:\u2002<\/jats:bold> These data suggest that PET\/CT is a useful tool for both, initial staging and follow\u2010up after therapy in patients with MALT lymphoma. Its sensitivity depends on disease location and stage at initial diagnosis.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00895.x","type":"journal-article","created":{"date-parts":[[2007,7,28]],"date-time":"2007-07-28T00:37:28Z","timestamp":1185583048000},"page":"205-209","source":"Crossref","is-referenced-by-count":107,"title":["Diagnostic accuracy of PET\/CT in patients with extranodal marginal zone MALT lymphoma"],"prefix":"10.1111","volume":"79","author":[{"given":"Chava","family":"Perry","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair","family":"Herishanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ur","family":"Metzer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Osnat","family":"Bairey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Ruchlemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonor","family":"Trejo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elizabeth","family":"Naparstek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Einat Even","family":"Sapir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Polliack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,6]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-09-2778"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.rcl.2004.08.008"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.8-5-438"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1080\/10428190600733499"},{"key":"e_1_2_5_6_2","volume-title":"World Health Organization Classification of Tumours. 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