{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T06:11:01Z","timestamp":1697091061473},"reference-count":10,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,8,3]],"date-time":"2007-08-03T00:00:00Z","timestamp":1186099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Here, we report a rare coincidence of heterozygous hemoglobinopathy (Hb) Stanleyville II and severe pernicious anemia due to autoimmune gastritis. Hb Stanleyville II is characterized by a single base exchange (AAC\u2192AAA) resulting in a substitution Asn\u2192Lys at position 78 of hemoglobin \u03b12\u2010chain. Under normal conditions this hemoglobinopathy does not cause any symptoms even if present as homozygous variant. However, in our case diagnosis of pernicious anemia was hampered by the absence of typical erythrocytic macrocytosis and hyperchromasia. In addition, interpretation of bone marrow smears was difficult as characteristic findings for pernicious anemia were little pronounced. All known reasons for the absence of typical cytomorphologic signs in pernicious anemia as underlying iron deficiency and thalassemia could be excluded.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00918.x","type":"journal-article","created":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T02:07:46Z","timestamp":1186452466000},"page":"360-362","source":"Crossref","is-referenced-by-count":3,"title":["Cytomorphologic signs of severe pernicious anemia obscured in a patient with heterozygous hemoglobin Stanleyville II"],"prefix":"10.1111","volume":"79","author":[{"given":"Andreas","family":"Draube","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens M.","family":"Chemnitz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Wickenhauser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Staib","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hallek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl\u2010Anton","family":"Kreuzer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,8,3]]},"reference":[{"key":"e_1_2_3_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.5147.282"},{"key":"e_1_2_3_3_2","doi-asserted-by":"publisher","DOI":"10.1590\/S0100-879X2000000900008"},{"key":"e_1_2_3_4_2","first-page":"387","article-title":"The association of Hb Stanleyville II with alpha\u2010thalassemia and Hb S","volume":"29","author":"Costa FF","year":"1987","journal-title":"Nouv Rev Fr Hematol"},{"key":"e_1_2_3_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-291X(83)80109-0"},{"key":"e_1_2_3_6_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197803232981203"},{"key":"e_1_2_3_7_2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1093\/ajcp\/75.3.291","article-title":"Profiles of black and Latin American patients having pernicious anemia. HLA antigens, lymphocytotoxic antibody, anti\u2010parietal cell antibody, serum gastrin levels, and ABO blood groups","volume":"75","author":"Carmel R","year":"1981","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_3_8_2","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1093\/ajcp\/75.1.96","article-title":"Pernicious anemia in blacks: a study of 64 patients from Washington, D.C., and Johannisburg, South Africa","volume":"75","author":"Solanki DL","year":"1981","journal-title":"Am J Clin Pathol"},{"key":"e_1_2_3_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM198211183072106"},{"key":"e_1_2_3_10_2","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.1132"},{"key":"e_1_2_3_11_2","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199202000-00028"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2007.00918.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2007.00918.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:33:36Z","timestamp":1697074416000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2007.00918.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,3]]},"references-count":10,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1600-0609.2007.00918.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2007.00918.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,3]]}}}