{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,13]],"date-time":"2026-09-13T03:13:05Z","timestamp":1789269185021,"version":"build-2803163510"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,8,3]],"date-time":"2007-08-03T00:00:00Z","timestamp":1186099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Toxoplasmosis is a rare but rapidly fatal complication that can occur following hematopoietic stem cell transplantation (HSCT). Over a 17\u2010yr period at our institutions, a definite diagnosis of toxoplasmosis was made in only two of 925 allogeneic HSCT recipients (0.22%) and none of 641 autologous HSCT recipients. These two patients received a conventional conditioning regimen followed by transplantation from an HLA\u2010matched donor; however, they developed severe graft\u2010vs.\u2010host disease, which required intensive immunosuppressive therapy. Despite prophylactic treatment with trimethoprim\/sulfamethoxazole, their immunosuppressive state, as indicated by a low CD4<jats:sup>+<\/jats:sup> cell count, might have resulted in toxoplasmosis encephalitis. Rapid and non\u2010invasive methods such as a polymerase chain reaction (PCR) test of their cerebrospinal fluid for <jats:italic>Toxoplasma gondii<\/jats:italic> and magnetic resonance imaging of the brain were useful for providing a definitive diagnosis and prompt therapy in these patients: one patient stabilized and survived after responding to treatment with pyrimethamine\/sulfodiazine whereas the other died of bacterial infection. In addition, retrospective PCR analyses of the frozen stored peripheral blood samples disclosed that detection of <jats:italic>T. gondii<\/jats:italic> preceded the onset of disease, indicating routine PCR testing of peripheral blood specimens may be an early diagnostic tool. It should be noted that when patients receiving HSCT have an unexplained fever and\/or neurological complications, PCR tests should be considered to avoid cerebral lesions and improve the outcome of the patients.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00919.x","type":"journal-article","created":{"date-parts":[[2007,8,7]],"date-time":"2007-08-07T02:07:46Z","timestamp":1186452466000},"page":"317-321","source":"Crossref","is-referenced-by-count":45,"title":["Toxoplasmosis encephalitis following severe graft\u2010vs.\u2010host disease after allogeneic hematopoietic stem cell transplantation: 17\u2003yr experience in Fukuoka BMT group"],"prefix":"10.1111","volume":"79","author":[{"given":"Yayoi","family":"Matsuo","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shoichiro","family":"Takeishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshihiro","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atsushi","family":"Nonami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshikane","family":"Kikushige","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuya","family":"Kunisaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenjiro","family":"Kamezaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liping","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Hisaeda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsuto","family":"Takenaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tomohiko","family":"Kamimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuju","family":"Ohno","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Eto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takanori","family":"Teshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hisashi","family":"Gondo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mine","family":"Harada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Nagafuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,8,3]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(04)16412-X"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-4758(97)01212-X"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702396"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/s00234-005-0018-3"},{"key":"e_1_2_6_6_2","first-page":"67","article-title":"Toxoplasma infection after human allogeneic bone marrow transplantation: clinical and serological study of 80 patients","volume":"1","author":"Derouin F","year":"1986","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_7_2","first-page":"549","article-title":"Toxoplasma gondii infection in marrow transplant recipients: a 20\u2003year experience","volume":"13","author":"Slavin MA","year":"1994","journal-title":"Bone Marrow Transplant"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702370"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.7883\/yoken1952.46.121"},{"key":"e_1_2_6_10_2","first-page":"159","article-title":"Prevalence of antibody to Toxoplasma gondii in Hyogo Prefecture, Japan: comparison at a 10\u2010year interval","volume":"43","author":"Khin Sane W","year":"1997","journal-title":"Kobe J Med Sci"},{"key":"e_1_2_6_11_2","first-page":"334","article-title":"Disseminated toxoplasmosis after CD34+\u2010selected autologous peripheral blood stem cell transplantation","volume":"85","author":"Nakane M","year":"2000","journal-title":"Haematologica"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0020-7519(98)00096-4"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1086\/317471"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1702457"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1034\/j.1399-3062.2000.020305.x"},{"key":"e_1_2_6_16_2","doi-asserted-by":"crossref","first-page":"2929","DOI":"10.1128\/JCM.38.8.2929-2932.2000","article-title":"Real\u2010time PCR for diagnosis and follow\u2010up of Toxoplasma reactivation after allogeneic stem cell transplantation using fluorescence resonance energy transfer hybridization probes","volume":"38","author":"Costa JM","year":"2000","journal-title":"J Clin Microbiol"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1086\/426447"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1128\/JCM.27.8.1787-1792.1989"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bmt.1700736"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199309303291403"},{"key":"e_1_2_6_21_2","first-page":"270","article-title":"MR imaging in toxoplasmosis encephalitis after bone marrow transplantation: paucity of enhancement despite fulminant disease","volume":"25","author":"Ionita C","year":"2004","journal-title":"Am J Neuroradiol"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2004-861537"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2141.2001.03135.x"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V99.4.1159"}],"container-title":["European Journal of Haematology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1600-0609.2007.00919.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1600-0609.2007.00919.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,12]],"date-time":"2023-10-12T01:33:11Z","timestamp":1697074391000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1600-0609.2007.00919.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,8,3]]},"references-count":23,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["10.1111\/j.1600-0609.2007.00919.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1600-0609.2007.00919.x","archive":["Portico"],"relation":{},"ISSN":["0902-4441","1600-0609"],"issn-type":[{"value":"0902-4441","type":"print"},{"value":"1600-0609","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,8,3]]}}}