{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T23:34:51Z","timestamp":1782603291098,"version":"3.54.5"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,8,3]],"date-time":"2007-08-03T00:00:00Z","timestamp":1186099200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2007,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>We report the case of an Epstein\u2010Barr virus (EBV)\u2010 and human immunodeficiency virus\u2010serum negative patient suffering from repeatedly relapsing classical Hodgkin\u2019s Lymphoma (cHL) associated with a histological picture of plasma cell\u2010hyaline vascular (PC\u2010HV) form of Castleman\u2019s disease (CD). The CD30\u2010 and CD15\u2010 positive, Reed\u2010Sternberg\/Hodgkin cells, only occasionally expressed the CD20 molecule, but not leukocyte common antigen and latent membrane protein\u20101. Single\u2010strand polymerase chain reaction failed to detect human herpesvirus 8 or EBV in the involved tissues. At the time of second relapse in July 2005, the clinical picture was characterized by a palpable right hypogastric mass, disclosed at physical exam, in the absence of other enlarged peripheral lymph nodes, subjective symptoms or laboratory profile alterations. Combined hybrid\u2010(18)F\u2010fluorodeoxyglucose positron emission\u2010computerized tomography (18F\u2010FDG PET\/CT) showed increased radionuclide uptake in multiple external iliac lymph nodes [standardized uptake value (SUV) of 7.4] and non\u2010palpable left supraclavicular lymph nodes (SUV of 5.8). Relapsing cHL in the context of mixed PC\u2010HV CD was documented in two of three surgically excised abdominal lymph nodes never previously enlarged or involved by any lymphoproliferative disease. Because of the limited disease extension and failure to induce continuous remission with previous conventional chemoradiotherapy, the patient was treated with six rituximab injections. This immunotherapy induced significant reduction in size of supraclavicular lymph nodes as evident at ultrasound (US) scan (&lt;1 vs. 2.5\u2003cm, post\u2010 vs. pretherapy), which was confirmed by the 18F\u2010FDG PET\/CT in October 2005, despite no modification in SUV of 4.2. 18F\u2010FDG PET\/CT also disclosed no radionuclide uptake by abdominal lymph nodes. Thus, a second course of four additional rituximab injections was given and subsequent 18F\u2010FDG PET\/CT indicated persistent, but reduced incorporation of radionuclide compared to the pretherapy value (SUV of 2.7) in the supraclavicular area and confirmed a normal metabolic activity in the iliac external lymph nodes. Because of uncertain persistent disease in the supraclavicular nodal site, involved\u2010field radiotherapy (RT) was delivered in that area as consolidation treatment. After completion of rituximab and RT for 16 and 14\u2003months respectively, US and 18F\u2010FDG PET\/CT exams were indicative of complete remission. This case is in concordance with previously published data suggesting that rituximab immunotherapy might be a valid option in the treatment of CD and also have a role in the management of relapsing cHL.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00952.x","type":"journal-article","created":{"date-parts":[[2007,10,3]],"date-time":"2007-10-03T06:59:24Z","timestamp":1191394764000},"page":"455-461","source":"Crossref","is-referenced-by-count":15,"title":["A case of nodular sclerosis Hodgkin\u2019s lymphoma repeatedly relapsing in the context of composite plasma cell\u2010hyaline vascular Castleman\u2019s disease: successful response to rituximab and radiotherapy"],"prefix":"10.1111","volume":"79","author":[{"given":"Lorenzo","family":"Falchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Capello","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Palumbo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annamaria","family":"Rauco","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Emili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Cianciulli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Pace","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincenzo","family":"Capparella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Liberati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna 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