{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T05:02:05Z","timestamp":1777525325612,"version":"3.51.4"},"reference-count":22,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T00:00:00Z","timestamp":1191456000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2008,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p> <jats:italic>Aim:\u2002<\/jats:italic>We aimed to compare the frequencies, clinical characteristics, and prognostic factors of peripheral T\u2010cell lymphoma (PTCL) vs. extra\u2010nodal natural killer (NK)\/T\u2010cell lymphoma and to characterize the subtypes of extra\u2010nodal NK\/T\u2010cell lymphoma. <jats:italic>Methods:\u2002<\/jats:italic>We reviewed 97 consecutive patients with PTCL and extra\u2010nodal NKT lymphoma from 2000 to 2006. During this period, a total of 780 patients with malignant lymphomas were treated in our center. The diagnostic criteria used were based on the WHO classification system of malignant lymphomas. <jats:italic>Results:\u2002<\/jats:italic>Extra\u2010nodal\u2010NK\/T\u2010cell lymphoma and PTCL comprised 5.0% (39\/780) and 7.4% (58\/780) of all cases. Of the PTCL cases, histology was PTCL\u2010NOS in 25, anaplastic large cell in 11, angioimmunoblastic T cell in 18 and other subtypes in four patients. Compared with PTCL, extra\u2010nodal NK\/T\u2010cell lymphoma was associated with a significantly inferior rates of complete remission (33% vs. 53%, <jats:italic>P<\/jats:italic>\u2003=\u20030.05) and 3\u2003yr overall survival (29.5% vs. 47.5%, <jats:italic>P<\/jats:italic>\u2003=\u20030.003). On multivariate analysis, extra\u2010nodal NK\/T\u2010cell histology was independently associated with decreased survival. Further analysis into this subtype showed the nasal variant (<jats:italic>n<\/jats:italic>\u2003=\u200325) differed significantly from extra\u2010nasal variant (<jats:italic>n<\/jats:italic>\u2003=\u200314) in terms of stage at presentation (stages III\/IV, 36% vs. 79%), international prognostic index scores (high intermediate or high IPI scores, 24% vs. 64%), complete remission rates (48% vs. 7%), and median survival (10\u2003months vs. 1\u2003month, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.0001). <jats:italic>Conclusions:\u00a0<\/jats:italic>Extra\u2010nodal NK\/T\u2010cell lymphoma was associated with a poorer prognosis compared with PTCL and is likely to comprise two distinct variants with different clinical behavior and prognosis.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00978.x","type":"journal-article","created":{"date-parts":[[2007,10,4]],"date-time":"2007-10-04T23:08:22Z","timestamp":1191539302000},"page":"55-60","source":"Crossref","is-referenced-by-count":51,"title":["Comparative analysis of extra\u2010nodal NK\/T\u2010cell lymphoma and peripheral T\u2010cell lymphoma: significant differences in clinical characteristics and prognosis"],"prefix":"10.1111","volume":"80","author":[{"given":"Soon Thye","family":"Lim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Siew Wan","family":"Hee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Quek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lay Cheng","family":"Lim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swee Peng","family":"Yap","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Er\u2010Li","family":"Loong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ivy","family":"Sng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonard Hwan\u2010Cheong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei\u2010Kim","family":"Ang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanne","family":"Ngeow","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chee\u2010Kian","family":"Tham","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lynette","family":"Ngo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Han","family":"Tan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Tao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,12,13]]},"reference":[{"key":"e_1_2_5_2_2","first-page":"189","volume-title":"World Health Organization Classification of Tumours: Pathology and Genetics of Tumours of Hematopoetic and lymphoid Tissues","author":"Banks PM","year":"2001"},{"key":"e_1_2_5_3_2","first-page":"76","article-title":"Prognostic significance of T\u2010cell phenotype in aggressive non\u2010Hodgkin\u2019s lymphomas. 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