{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,9]],"date-time":"2025-10-09T06:21:20Z","timestamp":1759990880661},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2007,11,15]],"date-time":"2007-11-15T00:00:00Z","timestamp":1195084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2008,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Burkitt lymphoma\/leukaemia (BL\/L) is a heterogeneous disease with respect to epidemiological patterns and cell origin. The occurrence of BL\/L with an immature phenotype raises the question whether this phenotype might be a consequence of early B\u2010cell transformation or, alternatively, a secondary feature of transformed, mature B cells. It also poses important clinical questions regarding diagnosis and therapeutic procedures. Here we describe the case of a 4\u2010yr\u2010old child with BL\/L and FAB L3 morphology, with phenotypic and genotypic characteristics of a CD10+ precursor B\u2010cell acute lymphoid leukaemia (ALL) associated with t(8;14)(q24;q32). Molecular analysis showed expression of <jats:italic>RAG1<\/jats:italic> and <jats:italic>RAG2<\/jats:italic> and an unmutated VDJC\u03bc immunoglobulin rearrangement coinciding with a lack of <jats:italic>AICDA<\/jats:italic> expression, indicating an immature B\u2010cell origin. His clinical response suggested that FAB L3 ALL with <jats:italic>MYC<\/jats:italic> rearrangement and an aberrant precursor B\u2010cell phenotype is clinically similar to BL\/L. Moreover, short, intensive chemotherapeutic protocols seemed to be beneficial. This case also allowed us to refine the description of cellular and molecular variants of BL\/L regarding the cell origin and pathogenesis of this biologically heterogeneous disease.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00992.x","type":"journal-article","created":{"date-parts":[[2008,2,13]],"date-time":"2008-02-13T09:21:34Z","timestamp":1202894494000},"page":"265-270","source":"Crossref","is-referenced-by-count":11,"title":["Burkitt lymphoma\/leukaemia transformed from a precursor B cell: clinical and molecular aspects"],"prefix":"10.1111","volume":"80","author":[{"given":"Rocio","family":"Hassan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fabricio","family":"Felisbino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudio 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