{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T06:23:25Z","timestamp":1763619805395},"reference-count":32,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,11,15]],"date-time":"2007-11-15T00:00:00Z","timestamp":1195084800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["European J of Haematology"],"published-print":{"date-parts":[[2008,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>In non\u2010Hodgkin\u2019s lymphoma (NHL), the majority of translocations involve the immunoglobulin heavy chain gene (<jats:italic>IGH<\/jats:italic>) locus, while a few involve the immunoglobulin light chain gene (<jats:italic>IGL<\/jats:italic>) locus, consisting of the kappa light chain gene (<jats:italic>IG\u03ba<\/jats:italic>) and the lambda light chain gene (<jats:italic>IG\u03bb<\/jats:italic>). Although many reports have dealt with the translocation and\/or amplification of <jats:italic>IGH<\/jats:italic> in NHL, only a few have identified <jats:italic>IGL<\/jats:italic> translocations. To identify cytogenetic abnormalities and the partner chromosomes of <jats:italic>IGL<\/jats:italic> translocations in NHL, we performed dual\u2010colour fluorescence <jats:italic>in situ<\/jats:italic> hybridisation (DC\u2010FISH) and spectral karyotyping (SKY) in seven NHL cell lines and 40 patients with NHL. We detected <jats:italic>IGL<\/jats:italic> translocations in two cell lines and nine patients: four patients with diffuse large B\u2010cell lymphoma, three with follicular lymphoma, one with extranodal marginal zone B\u2010cell lymphoma of mucosa\u2010associated lymphoid tissue and one with mantle cell lymphoma. Five distinct partners of <jats:italic>IG\u03bb<\/jats:italic> translocation were identified by SKY analysis: 3q27 in three patients, and 1p13, 6p25, 17p11.2 and 17q21 in one patient each. Three cases featured double translocations of <jats:italic>IGH<\/jats:italic> and <jats:italic>IGL.<\/jats:italic> These findings warrant the identification of novel genes 1p13, 6p25, 17p11.2 and 17q21.<\/jats:p>","DOI":"10.1111\/j.1600-0609.2007.00993.x","type":"journal-article","created":{"date-parts":[[2010,7,18]],"date-time":"2010-07-18T01:11:23Z","timestamp":1279415483000},"page":"143-150","source":"Crossref","is-referenced-by-count":10,"title":["Immunoglobulin light chain gene translocations in non\u2010Hodgkin\u2019s lymphoma as assessed by fluorescence <i>in situ<\/i> 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